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Top 30 Best Nootropic Supplements (Buyer’s Guide Review List)

Have trouble learning new information, recalling old memories, or even remaining focused for a long time? Is your inability to effectively make decisions throwing you back mentally and emotionally? If so, this is understandable, as slowed cognitive function can do those mentioned above and many other damages to one’s mindset. The absence of a positive attitude can give rise to distress, depression, and an increased risk of common flu and, worse, cardiovascular diseases.

For people wanting a solution, the first step is to acknowledge that something needs to be done. This could range from getting mental stimulation and physical exercise to improving lifestyle choices and nutritional aspects that lead to bettered blood pressure and sugar levels, among others [1]. However, nootropic supplements are usually sought to feel an immediate surge in brain power (within hours, for the matter). Undoubtedly, this is where our editorial team’s expertise comes into effect, as we’ve managed to gather 33 top-performing nootropic supplements in 2021. Without any further delay, let us reveal to everyone what we believe are the top contenders within this respective space.

The Top 33 Nootropic Supplements of 2021

Before heading straight to the contenders, it is imperative that we briefly introduce the process that led us to these solutions. Specifically, our editorial team sat down together to assess crucial factors that aided in deciphering the good from the bad. Our research involved studying the company, its processes, existing scientific evidence, and areas needing improvement, among others.

We also decided to include “popularity” because we rarely noticed substance in such solutions in the past. We like to make this point to support our belief that research is essential and that word of mouth doesn’t always work. More on the entirety of our ranking criteria will be expounded next. For now, here’s a summary of each of the 33 best nootropic supplements (in random order):

Ageless Brain: A blend of 11 brain-boosting ingredients
NeuroLive: A physician-developed solution with seven brain-nourishing micronutrients to improve brain function
Brain C-13: A natural remedy made with herbs by a doctor for optimum mental function
Brain Pill: It is the top-secret weapon to peak mental ability and mental processing speed
Golden Mind: Made with miracle technology, Golden mind serves advanced brain nutrients for memory retention
CogniBiotics: This advanced formula contains probiotics to promote healthy brain and gut functions
Nootropics: Nutrients in this proprietary blend are proven to enhance cognitive function
Hunter Focus: Get faster results from this premium supplement to improve mental performance
Mind Lab Pro: Proven in lab research, Mind Lab Pro is a highly effective solution for cognitive benefits
Memo Defend: A true work of art, Memo Defend is a pure and powerful solution for optimal brain function and cognitive benefits
Memory Hack: Using this, you can instantly improve your brain cells and memory
MemoSurge: An extremely effective supplement that enhances brain function immediately
NeuroActiv6: A breakthrough formula to offer brain and mental benefits
NeuroFuel: CILTEP®’s original formula that enhances cognitive performance within 30 minutes of your first use
Energy & Focus: By chewing on these functional gums, you will be able to boost your brain functions quite easily
Advantage: A powdered formula to boost your brain potential with natural nootropic ingredients
NooCube Brain Productivity: Contains healthy ingredients that enhance brain function
Nootrogen: This natural nootropic brain support enhance cognitive abilities
Neuro Focus +: A blend of natural ingredients to avoid mental fatigue and achieve optimal brain function
Alpha Brain: Made with carefully selected ingredients for daily cognitive support
OptiMind: A blend of premium nootropic ingredients designed to support mental focus and energy
Neuro: Neuro will improve your memory retention power and increase the potential of your brain by 100%
Performance Lab Mind: Performance Lab Mind is a modern nootropic supplement for sharper focus
ProMind Complex: A power-packed formula made with vitamins and plants to enhance cognitive function
PureHealth Research Ageless Brain: Clinically tested and scientifically proven solution for boosting brain cells and blood flow
Youthful Brain: Created by NASA’s Dr. Sam Walters for ensuring a youthful brain and cognitive abilities
BrainEssence: One of the world’s most profound nootropic supplements
Qualia Mind: A revolutionary mental support formula
ReMind Solution: Boost your mental performance with six different performance indicators with ReMind Solution
Vitaae: Improve your memory and mental energy levels by 90% with this “Brain Trick”
Synapse XT: A natural way to maintain healthy brain function and hearing
Mind & Mood: Number one solution to deal with stress, anxiety, and poor mental performance
Brain Boost:Developed by doctors to improve cognitive function and mental energy levels

Ageless Brain

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Formula Details
Company:Organixx
Major Components:It contains herbal nootropics supplements like Camu Camu, Cat’s Claw, Bacopa Monnieri, Cinnamon, Pau D’Arco, Cocoa Powder, Dragon’s Blood Resin Extract, and Guayusa
Guarantee: 365-day money-back guarantee
Serving Size:Two capsules a day
Starting Price:$54.95

Ageless Brain is a doctor-recommended brain supplement that aims to enhance mental acuity and brain function while also lowering inflammation through natural herbs. As explained by Dr. Melissa Gallagher, ND, CLT, “Herbal Nootropics are combinations of botanical compounds that improve cognitive function, enhance memory, balance neurotransmitters, and support executive functions.”

NeuroLive

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Formula Details
Company:Amy Myers MD
Major Components:A 1005mg-proprietary blend of Bacopa Monnieri, Mucuna Pruriens, Ginkgo Biloba, and SharpPS GREEN Phosphatidylserine, N-Acetyl Tyrosine (100mg), L-Theanine (100mg), and Vitamin B6 (5mg)
Guarantee: 90-day money-back guarantee
Serving Size:Two capsules/serving
Starting Price:$49.97

NeuroLive is a physician-formulated nootropic supplement trusted to serve as a foundation for optimal brain health, memory retention, and cognitive function. When Dr. Amy Myers, MD, formulated this solution, she allegedly considered seven brain-supporting nutrients. The goal is to provide brain cell regeneration support, balance neurotransmitters, promote healthy vasculature blood flow, and induce desired alpha brainwave patterns (to balance calmness and alertness).

Brain C-13

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Formula Details
Company:Zenith Labs
Major Components:DMAE (150mg), Acetyl-L Carnitine (Amino Acid) (150mg), Bacopa Monnieri (150mg), Turmeric (150mg), Ginkgo Biloba leaf extract(150mg), Phosphatidylserine (75mg), Dimethylglycine (75mg), and Huperzine A (300mcg)
Guarantee: 180-day money-back guarantee
Serving Size:Three capsules
Starting Price:$49.00

Another doctor-formulated nootropic supplement to have made our list is Brain C-13 which helps to improve brain function, brain cell growth and boost brain energy. As maintained on the official website, this formula celebrates the coming together of 13 natural herbs and minerals believed to promote memory function, mood, awareness, and quick thinking to say the least. Matter-of-factly, Dr. Ryan Shelton insists that Brain C-13 can go as far as prolonging the effects of aging on the brain.

Brain Pill

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Formula Details
Company:Leading Edge Health
Major Components:Vitamin B6 (5mg), Vitamin B12 (50mcg), Phosphatidylserine (100mg), Ginkgo Biloba leaf extract(100mg), DHA Complex (100mg), and other amino acids
Guarantee: 67-day money-back guarantee
Serving Size:Take two capsules of Brain Pill
Starting Price:$69.95

The team at Leading Edge Health strongly believes that their take on Brain Pill nootropic supplement can barricade the road yielding a life of memory loss and cognitive decline. The formula boosts brain energy. Dubbed “BrainPill,” this brain supplement is trusted to house clinically studied natural ingredients that tend to one’s memory not only now but also well into the aging stages of life. Other potential benefits of the Brain Pill include mental performance under pressure, better concentration, and higher productivity.

Golden Mind

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Formula Details
Company:Cymbiotika
Major Components:Phosphatidylcholine, Lion’s Mane mushroom, Rhodiola Rosea, L-Theanine, Organic Sea Buckthorn Oil, Gotu Kola, Green Tea, American Ginseng, Bacopa Monnieri, and Ocean Minerals
Guarantee: Unavailable
Serving Size:14 pumps
Starting Price:$50

Up to this point, our discussion was surrounding the best nootropic supplements delivered in capsules form. Cymbiotika’s Golden Mind is an oral spray that provides advanced brain nutrients using micelle technology. The Lion’s Mane mushroom in the formula is proven to support nerve growth factor and cognitive abilities. The formula targets the structure of the brain and the gut-brain axis, all while protecting both from the effects of aging.

CogniBiotics

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Formula Details
Company:biOptimizers
Major Components:30 billion CFUs of probiotics (i.e., L. casei, L. Rhamnosus, B. Animalis, B. Breve, B. Longum, L. Reuteri, L. Helveticus, B. Infantis, and L. Fermentum), 260mg of prebiotics (i.e., Organic Inulin, and Xylooligosaccharide) and, 280mg of a Chinese Herbal Blend
Guarantee: Money back guarantee of one year
Serving Size:Two capsules
Starting Price:$62.10

CogniBiotics is advertised as a mind, mood-enhancing probiotics supplement that can improve brain health, induce mental clarity, and motivate learning, memory, and focus. The inclusion of probiotics implies targeting the gut microbiome. Hence, this nootropic supplement may boost cognitive function at the gut-brain axis or, as explained by one source, “a bidirectional link between the central nervous system (CNS) and the enteric nervous system (ENS) of the body [2].”

Nootropics

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Formula Details
Company:Elm & Rye
Major Components:Vitamin B3 (30mg), Vitamin B6 (5mg), Caffeine Anhydrous (268mg), and a proprietary blend filled with Gamma-Aminobutyric, Bacopa Monnieri, Alpha GPC, L-Theanine, Phosphatidylserine, L-Theanine, L-Tyrosine, Huperzine-A, and Magnesium
Guarantee: 30-day money-back guarantee
Serving Size:Two tablets
Starting Price:$84.99

Elm & Rye created their take on nootropics supplements with emphasis placed on improving cognitive function and concentration. As a result, individuals can anticipate increased alertness, productivity, and focus. Our editorial team found astonishing Elm & Rye’s level of transparency on the topic of company efforts.

Hunter Focus

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Formula Details
Company:Roar Ambition
Major Components:Lion’s Mane Mushroom (500mg), Ashwagandha (300mg), Citicoline (250mg), Passionflower (250mg), Bacopa Monnieri (200mg), N-Acetyl L-Tyrosine (Amino Acid) (200mg), L-Theanine (200mg), Phosphatidylserine (100mg) and Maritime Pine Bark Extract(100mg)
Guarantee: Unavailable
Serving Size:Four capsules
Starting Price:$60

Hunter Focus is judged as a premium nootropic supplement that can potentially deliver clarity from “a world full of distractions.” Given that another goal for this solution is to increase productivity, the team at Roar Ambition claims to have invested their time studying scientifically-backed nutrients at clinically approved dosages. Regarding Roar Ambition, all their products are either made at facilities located in the U.S. or UK. In terms of what the team wants everyone to know, they said, “We stay at the forefront of nutritional research, developing products for fitness enthusiasts, gym warriors, amateurs, and professional athletes.”

Mind Lab Pro

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Formula Details
Company:
Major Components:Vitamin B6 (2.5mg), Vitamin B9 (100mcg), and Vitamin B12 (7.5mcg) as NutriGenesis, Cognizin, Bacopa Monnieri (150mg), Organic Lion’s Mane mushroom (500mg), Sharp-PS (100mg), N-Acetyl L-Tyrosine (175mg), L-Theanine (100mg), Rhodiola Rosea (50mg), and Maritime Pine Bark Extract (75mg)
Guarantee: 100% satisfaction guarantee
Serving Size:Two NutriCaps
Starting Price:$89.00

Mind Lab Pro is a nootropic supplement that contains 11 evidence-backed ingredients thought to target six significant pathways, including brain energy, brain chemicals, brain circulation, brain regeneration, brain protection, and brain waves for optimal mental performance. Furthermore, this formula is believed to target multiple brain-boosting activities at once rather than focusing on single taskers. Essential minerals and vitamins in the formula can slow cognitive decline and

Memo Defend

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Formula Details
Company:N/A
Major Components:Vitamin C (60mg), Niacin (2.5mg), Vitamin B6 (5mg), Folate (100mcg), Vitamin B12, and a 620mg-proprietary blend of Hawthorn, Garlic, Olive, Hibiscus, Buchu, Uva Ursi, Juniper, and Green Tea
Guarantee: 60 days money-back guarantee
Serving Size:One capsule
Starting Price:$69

Memo Defend was introduced to the market by long-time researcher Thomas Taylor. In his opinion, the formula that he created can support a healthy memory for anyone of any age and medical history. Besides advising people to sleep well, get in a daily dose of laughter, make appropriate lifestyle choices, drink plenty of water, and read from time to time, he believes that including Memo Defend can further heighten results.

Memory Hack

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Formula Details
Company:Nutrition Hack
Major Components:Ginkgo Biloba, St. John’s Wort, Choline, and L-Theanine
Guarantee: 180-day money-back guarantee
Serving Size:Two capsules
Starting Price:$69

Another brain supplement that appears to follow the trends of Memo Defend is Memory Hack. Though some companies have been listed as the makers, close to nothing about their existence is accessible. Additionally, the advertised benefits are over-the-top and promise individuals nothing but false hope. Specifically, Memory Hack has been touted for its ability to promote “total restoration of memory in six months.”

MemoSurge

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Formula Details
Company:N/A
Major Components:Phosphatidylserine, St. John’s Wort, N-Acetyl-L-Carnitine, and Bacopa Monnieri
Guarantee: Money back guarantee of 60 days
Serving Size:Two capsules
Starting Price:$69

One of the popular brain supplements (without mention of a manufacturer) on our list is MemoSurge, presented as a solution that challenges Big Pharma. Many of us supposedly have brain farts or a “senior’s moment” because of an avoided imbalance in brain chemicals. The latter is fundamental to this solution. It is trusted to fire up neurotransmitters and repair damaged brain cells while preventing brain shrinkage, protect the brain against cognitive decline, and, lastly, eliminate anxiety and insomnia.

NeuroActiv6

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Formula Details
Company:NaturalCell
Major Components:NeuroFactor (Coffee Fruit), Activin (Grape Seed), Cognizin (Citicoline), and Sensoril (Withania Somnifera)
Guarantee: 60 days money-back guarantee
Serving Size:One scoop
Starting Price:$49.95

NeuroActiv6 is an advanced polyphenol and brain superfood formula designed to improve clarity, focus, and mood, avoid mental fatigue, restore brain energy and overall health, induce a calming effect, and raise BDNF levels. BDNF, short for “brain-derived neurotrophic factor,” is crucial for long-term brain health, as it has been tasked with safeguarding neuronal survival and growth. In addition, it is said to participate in neuronal plasticity, which is what drives our learning and memory functions [3].

NeuroFuel

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Formula Details
Company:Natural Stacks
Major Components:Vitamin B6 (5mg), Artichoke (900mg), Acetyl L-Carnitine (Amino Acid) (750mg), L-Phenylalanine (500mg), and Coleus Forskohlii (20mg)
Guarantee: 30 days money-back guarantee
Serving Size:Three capsules
Starting Price:$29.95

Natural Stacks’ NeuroFuel is “the original CILTEP formula for enhanced focus, deep concentration, and improved memory.” It is proven to boost mental processing speed and overall mental and physical performance. Out of all the best nootropic supplements found on this list, this one takes the cake because it may deliver a brain surge within 30 minutes of taking a serving. How so? As it turns out, NeuroFuel is one of the top nootropic stacks and has been designed to fuel neurotransmitters, and consequently, promote more significant signaling between healthy brain cells. It also supports brain cell development, cognitive performance, and mental energy.

Energy & Focus

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Formula Details
Company:Neuro
Major Components:Natural Caffeine (40mg), L-Theanine (60mg), Vitamin B6 (60% Daily Value), and Vitamin B12 (100% Daily Value)
Guarantee: A satisfaction guarantee
Serving Size:One gum
Starting Price:$21

If capsules, tablets, or even oral sprays aren’t convincing enough as delivery methods, there’s another one that we’ve rarely seen. Energy & Focus is the Neuro team’s take on a nootropic stack that provides fuel for the mind that will improve mental performance and overall mental function. As for its delivery, these are gums! That said, in the team’s opinion, big goals require equivalent energy levels. Bearing the latter in mind, they’ve considered simple ingredients that do the job while also upkeeping mental endurance and maximum bioavailability.

Advantage

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Formula Details
Company:NooBru
Major Components:Alpha GPC (120mg), L-Theanine (200mg), Ashwagandha (100mg), Choline Bitartrate (250mg), Vitamin B5 (30mg), Huperzine A (200mcg), BioPerine (2mg), PhosphatidylSerine (50mg), N-Acetyl L-Tyrosine (50mg), Sulbutiamine (1mg), and Vitamin B6 (2mg)
Guarantee: 100% risk-free guarantee
Serving Size:One scoop with water
Starting Price:$84.19

Advantage by NooBru has been created to “give the brain everything it needs to unlock its peak performance.” According to the team, each serving reflects 11 active ingredients selected in reviewing the science alongside medical doctors to guarantee an advantage like no other. This is a powdered supplement; hence, individuals simply must add it to their bottled waters, give a good shake, and they should be good to go.

NooCube Brain Productivity

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Formula Details
Company:
Major Components:Alpha GPC (50mg), Huperzine A (20mg), Cat’s Claw (175mg), Bacopa Monnieri (250mg), Oat Straw (150mg), L-Theanine (100mg), L-Tyrosine (250mg), Vitamin B1 (1.2mg), Vitamin B12 (2.4mcg), Biotin (50mcg), Marigold Extract (20mg), Resveratrol 99% (14.3mg) and Pterostilbene (140mcg)
Guarantee: 60 days money-back guarantee
Serving Size:Two capsules
Starting Price:$59.99

The NooCube Brain Productivity nootropic stack formula represents a synergistic blend of best nootropic supplements to support and enhance focus levels, mental speed and boost memory. Within 30 minutes of taking each serving (lasting anywhere between 8 and 10 hours), individuals can anticipate a swift transition from low to sufficient energy and cognitive function. As stated on the official website, this one of the best nootropic stacks formulas was designed by top neuroscientists, emphasizing clinical trials, rigorous testing, and safety and efficacy.

Nootrogen

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Formula Details
Company:Vita Balance
Major Components:The nootropics stack contains DMAE Bitartrate, L-Glutamine HCL, Glutamic Acid, Green Tea, Bacopa Monnieri, Inositol, N-Acetyl L-Tyrosine, and others
Guarantee: Unavailable
Serving Size:Two capsules
Starting Price:$29.95

Nootrogen is touted as the “ultimate nootropic” that helps to improve cognitive function, energy, brain health, and focus levels and helps manage everyday stress. Based on the creators’ claims, the chosen ingredients have the potential to stimulate the brain’s natural synaptic plasticity, and thus, grow productivity levels, promote sharp thinking, and simply get everyone by daily. Regarding best nootropic supplements, Vita Balance stands by its passion for the miracles that stem from natural ingredients.

Neuro Focus +

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Formula Details
Company:Nuzena
Major Components:DMAE bitartrate, amino acids, Maritime pine bark extract, green tea extract, and bilberry fruit extract
Guarantee: Unavailable
Serving Size:Two capsules
Starting Price:$30

Neuro Focus + is a nootropic stack formula designed by health professionals to provide optimal brain function. When taken as directed, individuals can forestall benefits such as mental clarity and focus, concentration, and feelings of relaxation during stressful times. For people wondering what’s so special about Nuzena, two significant facets among several others come to mind. First, they include clinically proven ingredients, with a summary provided on the official website on each one. This is absolutely one of the top nootropic stacks in the market.

Alpha Brain

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Formula Details
Company:Onnit
Major Components:L-Tyrosine, L-Theanine, Oat Straw, Phosphatidylserine, Alpha GPC, Bacopa Monnieri, and Huperzine A
Guarantee: 100% satisfaction guarantee
Serving Size:Three capsules
Starting Price:$34.95

Alpha Brain has been formulated to boost memory, mental energy, and focus. To be more precise, the Onnit team believes that individuals can now “focus even with the most complex tasks” and that their ability to recall information heightened. Onnit Fuel Blend (60mg) housing L-Leucine and Pterostilbene to optimize blood flow to the brain.

OptiMind

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Formula Details
Company:AlternaScript
Major Components:L-Taurine, Phosphatidylserine, Natural Caffeine, GABA, L-Tyrosine, Alpha Lipoic Acid, and Huperzine A. Additionally, each serving contains Vitamin D (9.6mcg), Thiamin (1.5mg), Vitamin B12 (500mcg) and Calcium (10mg)
Guarantee: Unavailable
Serving Size:One capsule
Starting Price:$29.95

Next, OptiMind is a nootropic supplement intended to improve focus, brain health, cognitive functions, and mental performance within 12 weeks. An exceptional feature belonging to this nootropic stack supplement is that its creators pledge for long-term results. Regularly taking OptiMind servings may lead to verbal learning, cognitive and mental performance, retention of new information, and visual information processing.

Neuro

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Formula Details
Company:Oweli
Major Components:Phosphatidylserine, B vitamins, Bacopa monnieri, inositol, and DMAE
Guarantee: 100 days money-back guarantee
Serving Size:Two capsules
Starting Price:$29.99

Neuro by Oweli is a nootropic stack trusted to promote healthy brain function, focus, and alertness and enhance memory retention by targeting neuroplasticity. Like Mind Lab Pro, this nootropic supplement is not tailored for one specific target market, as it can be benefited by working professionals, seniors, students, and competitors. Though in some ways, the Oweli team wants to induce short-term results, at large, they appear to be thinking bigger.

Performance Lab Mind

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Formula Details
Company:Performance Lab
Major Components:Performance Lab Mind contains Cognizin (250mg), Sharp-PS (100mg), Ajipure L-Tyrosine (250mg), and Maritime Pine Bark Extract (75mg)
Guarantee: 30 days money-back guarantee
Serving Size:Two capsules
Starting Price:$69

After seeing long nootropic stacks formulas, we’re happy to finally review another simple thought process that made the top contenders of 2021. Performance Lab’s Mind is believed to promote peak brain power and health while resisting burnouts. Captivatingly, the team affirms that Performance Lab Mind can boost brain energy up to 13.6%, and is likely to tend to focus, memory, speed, motivation, and recovery as seen fit.

ProMind Complex

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Formula Details
Company:N/A
Major Components:St. John’s Wort (250mg), L-Glutamine (150mg), Phosphatidylserine 4% (125mg), Bacopa Monnieri (120mg), N-Acetyl L-Carnitine Hydrochloride (50mg), Vinpocetine (2mg), Huperzine A (10mcg)
Guarantee: 60 days money-back guarantee
Serving Size:One capsule
Starting Price:$69

ProMind Complex is advertised as a brain function support that finds and eliminates a specific type of bacteria judged as the culprit for memory loss. Supposedly developed by Carl Henderson, who carries decades of experience in the supplements’ realm under his belt, this simple nootropic stack formula is said to go a long way.

PureHealth Research Ageless Brain

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Formula Details
Company:PureHealth Research
Major Components:Niacin (10mg NE), Vitamin B6 (2.5mg), Green Tea Extract (250mg), and a 600mg-proprietary blend of Caffeine Anhydrous, GABA, Bacopa Monnieri, Alpha GPC, L-Theanine, Phosphatidylserine, L-Tyrosine and Huperzine-A
Guarantee: One-year money-back guarantee
Serving Size:One capsule
Starting Price:$44.10

Ageless Brain is a memory, focus, and clarity-supporting supplement that rejoices from tested ingredients in clinical trials for utmost neurologic wellness. In addition, individuals can anticipate a reduction in feelings of anxiousness and brain fog. At PureHealth Research, an entity encompassing skilled experts, innovative and talented people, the goal is “to help people reclaim the control of their own health.”

Youthful Brain

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Formula Details
Company:Vitality Now
Major Components:Vitamin B12 (1000mcg) and a 280mg- Clear Mind Formula proprietary blend of Bacopa Monnieri, Phosphatidylserine, Ginkgo Biloba, and Huperzine A
Guarantee: Six months money-back guarantee
Serving Size:Two capsules
Starting Price:$64.95

Formulated by a brain health specialist and former NASA scientist, Dr. Sam Walters, Youthful Brain is a nootropics stack supplement believed to combat commonly experienced cognitive issues and brain health issues associated with mild memory loss. His strategy for this supplement involved relying on nutrition that astronauts allegedly ingest to keep their minds sharp. That said, one source [4] insists that the claims made by Dr. Sam that “diacetyl often passes through the blood-brain barrier and can lead to deposits in the brain” lacks substance.

BrainEssence

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Formula Details
Company:PureEssence
Major Components:Acetyl L-Carnitine (500mg), Bacopa Monnieri (300mg), Organic Ashwagandha (200mg), Mucuna Pruriens (200mg), Schizandra Extract (200mg), and more
Guarantee: 90-day satisfaction guarantee
Serving Size:Two tablets
Starting Price:$29.99

BrainEssence is a dietary supplement that delivers nootropic nutrients and botanicals that improve one’s mental support. Mainly, it could drive focus and energy levels, revamp one’s memory and mental clarity, induce problem-solving and neurogenesis, maintain healthy stress response and overall brain health.

Qualia Mind

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Formula Details
Company:Neurohacker Collective
Major Components:Bacopa Monnieri (300mg), Rhodiola Rosea (300mg), DL-Phenylalanine (300mg), Uridine-5 (250mg), N-Acetyl L-Tyrosine (250mg), Taurine (200mg), L-Theanine (200mg), Alpha GPC (200mg), Cognizin (150mg), Organic Coffeeberry (129mg), Mucuna Pruriens (100mg), Phosphatidylserine (100mg), and several others
Guarantee: 100-day satisfaction guarantee
Serving Size:Two capsules
Starting Price:$59

Qualia Mind is a supplement that contains 28 ingredients believed to enhance focus, brain function, memory, and mental clarity across some of our major neurological systems. The Neurohacker Collective team shared that their strategy targeted and regulated vital neurotransmitters, the brain-derived neurotrophic factor, prefrontal cortex activity, neuron and synaptic functions, and other pathways critical for brain function. According to the claims made, this approach is what permits long-term cognitive health benefits.

ReMind Solution

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Formula Details
Company:N/A
Major Components:Bacopa Monnieri, N-acetyl L-carnitine (NAC or NALC), L-glutamine, Ginkgo Biloba, and Huperzine A
Guarantee: 60-day satisfaction guarantee
Serving Size:One tablet
Starting Price:$69

ReMind Solution is an advanced cognitive enhancer that might sharpen the mind, brain function, promote clear thinking, and induce laser focus. This solution has been advertised as having a lot of demand. Yet, the listed prices do not seem to depict the completeness of ReMind Solution, as it significantly fails on the factor of transparency.

Vitaae

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Formula Details
Company:SANESolution
Major Components:Vitamin D (125mcg), Magnafolate (667mcg), Cognizin (100mg), MicroActive (50mg), and 1800mg VitaalMind Proprietary Blend of Acetyl L-Carnitine HCl, L-Carnitine Tartrate, Gymnema Sylvestre, and Omega-3 Fatty Acid
Guarantee: One-year satisfaction guarantee
Serving Size:Three capsules
Starting Price:$46.95

Vitaae is an anti-aging clinical research formulation that might allow consumers to “leave behind brain fog and improve mental clarity while keeping memories safe.” SANESolution insists that the included ingredients, which have been clinically studied, could optimize brain health utilization by 13.6% and membrane turnover by 26%. Among top nootropic supplements, Vitaae will boost brain function and cognitive performance. Furthermore, it avoids mental fatigue, brain fog, and cognitive decline.

Synapse XT

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Formula Details
Company:N/A
Major Components:Riboflavin (1.2mg), Vitamin B6 (1.7mg), Folate (800mcg), Magnesium (200mg), Potassium (200mg), Hibiscus (350mg), Garlic (200mg), Hawthorn Berry (200mg), and Rosemary (140mg)
Guarantee: Unavailable
Serving Size:Two capsules
Starting Price:$69

Another popular nootropic supplement is Synapse XT, which is broadcast to supercharge and maintain a healthy brain function and hearing. Why target hearing? One source explained that hearing is a brain activity that delivers electrical impulses via the auditory nerve to the ears. Once they reach the brain, only then are we able to recognize sounds [5]. Thus, people who have mild hearing loss might be at risk of an overwhelming cognitive function. As captivating as this all might sound, we aren’t certain as to who might have formulated Synapse XT.

Mind & Mood

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Formula Details
Company:UpWellness
Major Components:Vitamin B6 (10mg), GABA (200mg), L-Theanine (200mg), Rhodiola Rosea (200mg), 5-HTP (200mg), L-Tyrosine (100mg), Passiflora Incarnata (50mg), and Saffron (30mg)
Guarantee: 60 days money-back guarantee
Serving Size:Two capsules
Starting Price:$57

Mind & Mood is an adaptogenic herbal and nutritional formula that supports a relaxed nervous system, neurotransmitter signaling, mood and energy, and enhanced attention to detail. The brain pills also eliminate brain fog, improve brain function, develop new brain cells, and target brain pathways. Formulated by Dr. Joshua Levitt, this nootropic supplement is a simple one that celebrates nothing but herbs that draw upon the science of conventional and naturopathic medicines. At UpWellness, the goal is to redefine the meaning of “nutrients,” which aren’t only derived from food and one’s overall way of life.

Brain Boost

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Formula Details
Company:Vital Plan
Major Components:Lion’s Mane Mushroom Extract (500mg), Cat’s Claw Extract (350mg), Bacopa Monnieri (300mg), Sensoril Ashwagandha (125mg), and Ginkgo Biloba (120mg)
Guarantee: Unavailable
Serving Size:Four capsules
Starting Price:$48

Finally, we have a physician-formulated natural nootropic blend called Brain Boost that might promote brain and cognitive health despite modern-day challenges and aging processes. In addition to targeting the brain, this formula also fortifies the immune system and gut microbiome. Regarding the gut microbiome, Dr. Bill Rawls explained that “keeping the bad guys in check prevents the microbiome from becoming an undue burden on the brain.” As for immune function, it is a vital component to “free up the brain to function at its best.”

How Our Top Picks Measure Up to A Customizable Ranking System

At this stage in the guide, it should be no surprise that most solutions are unique in their concept and execution. Likewise, some solutions hit the mark, while others still lack to affirm any results. In the majority of the substance-less supplements, the founding factor was popularity or unattainable benefits/claims. This goes to show that one aspect is never enough to evaluate usefulness. So, what else should we be looking at? This is where our customizable ranking system comes into effect. The following is a summary of the deciding factors that we viewed as being crucial. Bear in mind that these may vary on a case-by-case basis:

Company & Transparency

Simply knowing a supplement and its contents tells us nothing about its legitimacy. Why are we looking at that solution if a company chooses to remain silent or fails to reveal itself? The number one factor that should hold no matter the product is its creator and their level of transparency in keeping everyone informed. A discrepancy in either one is a warning that needs to be immediately picked up on.

Manufacturer Standing

Another equally important factor is the manufacturer’s standing; how else would we have a supplement, right? That said, just because a manufacturer could bring a solution to life, it doesn’t make them saviors. In assessing such components in a supply chain, individuals need to verify their legitimacy, whether they comply with existing regulations, their responsiveness, and their overall presence within the supplements industry. Failing on any one of these counts should be questioned.

Scientific Evidence & Clinical Dosing

The FDA does not approve natural dietary supplements and smart drugs. The organization is sure to intervene when it involves pharmaceutical drug products or to assess product labels. Fortunately, the science regarding natural ingredients is only starting to develop further, so individuals are highly recommended to research listed components before placing an order.

Advertised Benefits

Advertised benefits are a favorite among members of our editorial team because we’ve seen a handful of providers make outlandish claims to lure in consumers. It should be carefully reviewed if a nootropic supplement insists that poor cognitive function and memory loss are completely reversible or can help consumers regain brain function equivalent to one’s time as a youth. No nootropic supplement we know of can magically transform one’s cognitive function in the short run. Therefore, individuals need to consider brain support systems with the mindset of attaining relief over the long run.

Uniqueness

Uniqueness is a factor that can be defined in multiple ways while selecting smart drugs. To us, it’s practically anything that makes a company stand out. Hence, any statements including but not limited to doctor/physician-formulated, third-party lab testing and availability of results, education material, patented and proven ingredients, money-back guarantees, and efforts towards the betterment of society were sure to draw us in for further analysis.

Value for Price

Finally, we have value for the price, which is determined based on the number of factors a supplement checks off. If we have two solutions priced similarly but contain one and several desirable factors respectively, it seems reasonable to go with the second option.

The Scientific Outlook into Nootropic Supplements

So far, this guide delved into the proposed top 33 supplements of 2021 and the ranking system that gave each solution such a renowned title. After spending some time on each formula, we noticed that many ingredients were recurring. Does this mean that these are the ones to have the most scientific backing? Well, we’d hope so, and this is the main reason why we decided to see for ourselves what the scientific outlook into the best nootropic supplements suggests. The top five recurring ingredients were studied to keep things direct, but in general, we recommend going over each one before arriving at a final verdict. Nevertheless, listed below is a brief on each one:

Citicoline

Citicoline is chemically identical to CDP-choline and has been shown to increase the effect of neuroplasticity while promoting acetylcholine production. A 2015 review that looked at the pharmacokinetics and pharmacodynamics of citicoline summarized that its ingestion could contribute to neuronal repair and cognitive impairment of any kind. The researchers also noted that long-term oral intake is likely safe, with the dose ranging between 500mg to 2000mg per day. Above all, “citicoline has been recently shown to increase SIRT1 protein expression, and this is strongly involved in its neuroprotective actions [6].”

Phosphatidylserine

Phosphatidylserine is a fatty substance called phospholipid that essentially covers and protects neuronal cells while helping with the transfer of messages. WebMD further highlighted that it plays a significant role in “keeping the mind and memory sharp [8].” A 2015 scientific literature across MEDLINE articles summarized that phosphatidylserine is essential for healthy nerve cell membranes and myelin.

Bacopa Monnieri

Also referred to as Brahmi, water hyssop, gratiola, and herb of grace, bacopa monnieri remains a top contender among Ayurvedic practitioners. A 2012 study that looked at the effect of this plant on attention, cognitive processing, working memory, and cholinergic and monoaminergic functions in healthy elderly found improvements worth recording. Specifically, it took 12 weeks of ingesting (300mg and 600mg) to improve the facets above. The reason for this rests in the herb’s potential in suppressing AchE (acetylcholinesterase) activity [10].

Huperzine A

Huperzine A is a cholinesterase inhibitor, meaning that it might improve neurotransmitter levels. A rat-based model that looked at its effects reported that improvements by Huperzine A on cognitive dysfunction do hold, adding that this was seen on the cholinergic system, on oxygen free radical system, and regarding energy metabolism [12].

L-Theanine

L-theanine is a type of amino acid and a natural constituent found in tea. Amino acids are capable of dealing with depression and anxiety. The amino acids furthermore make your mind calm and relaxed. According to a 2019 randomized, placebo-controlled, crossover, and double-blind trial that looked at the possible effects of taking L-theanine for four weeks, the outcomes were deemed favorable. In particular, the researchers discovered that it “has the potential to promote mental health in the general population with stress-related ailments and cognitive impairments [14].”

Frequently Asked Questions About Nootropic Supplements

Q: What is a nootropic supplement?

A: Nootropic is a dietary supplement developed to naturally optimize one’s awareness by tapping into different areas of cognitive function. It is generally believed to fill in related voids such as memory loss, inability to retrieve old information and learn new ones, lack of focus and energy, etc.

Q: What is neurogenesis?

A: Neurogenesis is a process through which new neurons are created in the brain, and such creation is fundamental in regulating cognitive functions and mood.

Q: Are nootropic supplements safe to take?

A: At large, nootropic supplements and smart drugs are deemed safe because of the use of natural ingredients and clinical dosing reported in existing studies. However, the best thing to do before placing an order is to provide a health practitioner with the supplement facts for a second opinion.

Q: What are the side effects of nootropic supplements?

A: Some possible side effects of taking brain supplements include insomnia, blurry vision, high blood pressure, fast heart rate, circulation problems, and possibly addiction summarizes WebMD, but these are for prescription nootropic supplements and not dietary supplements [18].

Q: Who is a suitable candidate for nootropic supplements?

A: Nootropic dietary supplements can be taken by working professionals, athletes, students, and the elderly. That said, individuals should make sure that their preferred brand identifies the target market before investing. The simple explanation for this is that students and seniors are likely to tolerate a solution differently. A similar argument could be made when comparing a healthy person to someone who has a medical history.

Q: Are nootropic supplements legal?

A: Yes, nootropic supplements are entirely legal in the U.S. but may be considered prescription drugs elsewhere. So, it is the consumer’s responsibility to confirm legality regarding smart drugs in different regions.

Q: Can people become dependent on nootropic supplements?

A: Some brain supplements and smart drugs can create dependencies. In the case of our top smart drugs picks, individuals may view caffeine as addictive; however, since safe doses are of importance, its presence is unlikely to have such a gruesome effect.

Q: How do you know an advertised nootropic supplement is legitimate?

A: Not all nootropic supplements are legitimate, as a handful of scammers are out there trying to profit from an individual’s concerns. To assess legitimacy, we recommend everyone refer to our ranking system, which outlines crucial deciding factors.

Q: Are all nootropic supplements natural?

A: Not all nootropic supplements are formulated to be natural, as synthetic options are available. There are lab-made options as well, but our list focuses on natural solutions.

Q: Does The FDA approve smart drugs?

A: Nootropics and smart drugs are dietary supplements and therefore are neither regulated nor approved by the FDA. The FDA’s approval is not even needed, but this would signify the need to investigate solutions before placing an order thoroughly.

Q: Are there any foods that have similar effects to taking nootropics and smart drugs?

A: As maintained by Harvard Health Publishing, foods likely to enhance brain power include green, leafy vegetables, fatty fish, berries, tea and coffee, and walnuts [19].

Q: Is there a difference between nootropics and cognitive enhancers?

A: No, “cognitive enhancers” is another term for “nootropics.”

The Top 33 Nootropic Supplements of 2021 Final Verdict

Ultimately, nootropics are dietary supplements that intend to maximize cognitive function and brainpower. We must emphasize the ingredients list, which encompasses nothing but natural ingredients across all 33 supplements. Undeniably, we’ve seen a fair share of unique approaches and others that meet market standards. Regardless, the contents of each formula (for the most part) have clinical backing. The latter is uplifting for those in dire need of an energy hike, focus and concentration for hours on end, and a stimulus like no other.

While there are good options out there, there are also equally bad ones. There are at least five on our list that merely passed the test based on “popularity.” As repetitive as this might be, individuals need to realize that products lacking company/manufacturer information, an official website outside of a sales page, and clear supplement facts, to name a few, should be neglected because those are decoys that many people continue to fall for. That’s why having a ranking system is so crucial.

Moving forward, individuals ought to make it a habit to refer to our ranking system and to customize it to their likings before finalizing a pick. Until next time, we hope that we’ve shed light on the significance of extensive research, scientific backing, and the need for transparency on the company’s side instead of blindly trusting misinformation.

RELATED:Top 30 Best Medicinal Mushroom Supplements to Buy for 2022

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.

Disclaimer:

Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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