Top 30 Best Mushroom Supplements That Work to Buy (2022)

Medicinal mushrooms are a group of proven organic mushrooms that are considered best for various areas of health. Deemed generally safe to ingest, the research community is currently on a mission to reintroduce the world to mushrooms, but this time not as a vegetable but as a health-promoting ingredient thanks to promising results signifying their biologic effects. Who can forget their combined antioxidant, antiallergic, cardiovascular protective, antibacterial, and detoxification properties, among several others? As preliminary results continue to impress the public, it only made sense for our editorial team to present some of the best medicinal mushroom supplements of 2021.

Given that more and more producers are working to tell a story through their respective formulas, it becomes imperative that we distinguish the promising from the deceptive. After further investigation, our panel developed a guiding framework encompassing features to be watchful of. As a result, we have not one but a whopping 29 preferred mushroom supplements worth conversing about. The following guide will dive into our thought process, how we arrived at the best mushroom supplements of the year, the entirety of the guiding framework, the scientific outlook into medicinal mushrooms, and much more.

The Best Medicinal Mushroom Supplements of 2021

Listed below are the top 29 medicinal mushroom supplements for 2021, along with a brief on their distinctive features. Typically, we like to provide information on the mushroom supplement itself, the company behind it, and anything that draws us closer to the solution. The latter is often represented in the form of additional features (i.e., lab reports, medical advisory board, education resources, etc.) that aren’t mandatory per se yet allow the supplement to stand out. Well, without giving too much away, here are our picks for the best mushroom supplements:

5 Mushrooms Reserve Blend: Made with 5 top quality mushrooms
Brain Forza Organic Lion’s Mane Mushroom: Organic Lion’s Mane Mushroom for healthy brain functioning
Botany Cordyceps Militaris Extract: Lab testing has verified this Caterpillar Fungus powder
Mushroom Blend Tincture: Promoting four pillars of health
Lion’s Mane: A functional mushroom company that offers high-end mushroom supplements
Earth Nutri Performance Energy + Focus: Enhances your mental performance throughout your day
Four Sigmatic Mushroom Blend Mix: Made with top ten mushrooms for everyday use
FreshCap: Mushroom capsules that provide energy and endurance
Genius Mushrooms: There are a wide variety of mushrooms offered by this company
Supershroom Powder: Four of the best immune-boosting mushrooms combined
Mushroom Vitality: It includes the world’s most powerful mushrooms in a revolutionary mushroom supplement
MindHoney: A great daily cognitive supplement
MUD\WTR Starter Kit: An organic mushroom supplement that supports youthfulness
Mushroom Defense: The immune complex is designed to promote health and immunity
Mushroom Revival: Mushroom revival supplements come with a 5-second wellness routine
MycoPhyto Complex: Fortifying the immune system in a complete manner
Shroom Tech SPORT: Maintain cardiovascular endurance and cellular energy
7M+: A Fermented mushroom supplement that helps to fight colds, flu, and bacteria
WonderDay Mushroom Gummies: Doctor-formulated adaptogens strengthen your immune system and brain function
Pure Essence MyPure Lion’s Mane: Supports brain health and immunity with organic mushrooms
Real Mushrooms: Mushroom supplements that are 100% pure and organic
Shroomy Mushroom Extract Gummies: It is the first-ever mushroom gummy product in the world
Spore Life Sciences Focus Performance: The adaptogens in this product support healthy immune function
TheDrug.Store: Medicinal mushroom supplements of the highest quality for optimum health
VidaCap: Best medicinal mushroom supplements in the world
Adaptogen Recovery: Herbal formula for boosting immunity and improving health
Brain Boost: A physician-formulated supplement that promotes the optimal use of the brain
Immune Support: A wide range of nutritional ingredients are contained in this mushroom supplement for optimal immunity
Magic Mushroom: With this relaxing chocolate formula, you’ll feel calm and relaxed

5 Mushrooms Reserve Blend

Important Details
Company: Hippie Farms
Key Components: Organic Lion’s Mane (350mg) and Reishi mushrooms, Cordyceps (350mg), Chaga (350mg), and Turkey Tail Mushrooms (350mg)
Dosage: Take three capsules a day
Guarantee: NA
Starting Price: $29.99

Formulated by Hippie Farms, 5 Mushrooms Reserve Blend is one of the best mushroom supplements that could support the immune system, energy levels, cognitive and nerve functions, and mood. As the Hippie Farms team maintained, their strategy entailed using organic mushrooms and confirming that their solutions have been third-party tested for potency, quality, and purity. One specific feature we’ve never seen before is the hip nature of this brand. This is so unlikely, but it gives off a playful vibe that cheers everyone to enjoy mushrooms.

Organic Lion’s Mane Mushroom

Important Details
Company: Brain Forza
Key Components: Red Reishi, Turkey Tail, Cordyceps Mushrooms supplements
Dosage: Serve three capsules
Guarantee: 90-day money-back guarantee
Starting Price: $23.86

Established in 2010, Brain Forza is presently operating from Vancouver, British Columbia. Founded by a natural science enthusiast, Greg Loukas, Brain Forza can be perceived as the one-stop shop for all fitness and natural health solutions. To the topic of mushrooms, all their products are said to have been 100% organically grown and made in the U.S. Organic Lion’s Mane Mushroom supplement has been developed to enhance brain health, nerve function, and cognitive function. With each serving delivering 1,500mg of full-spectrum Lion’s Mane Mushroom, we can assure you that this is by far the best mushroom supplement concentration using a single mushroom strain.

Botany Cordyceps Militaris Extract

Important Details
Company: Science.Bio
Key Components: The mushroom supplement contains Cordyceps Militaris Mushroom extract
Dosage: Take 500 mg per serving
Guarantee: 30-day satisfaction guarantee
Starting Price: $23.99

Unlike other mushroom supplement companies, Science.Bio is a company devoted to providing reference materials of the highest quality for life science research. Driven by Science, the team pledges to promote innovation by committing to client goals, partaking in sustainable operations, supporting public advocacy, and ensuring employee satisfaction, among others. What might the outcome be? One example is that of the Botany Cordyceps Militaris Extract supplement. This is one of the best mushroom supplements delivering 500mg of Cordyceps Militaris Mushroom per serving, the team at Science.Bio vouch that this supplement (and every other) is free from contaminants, excipients, and flow, ensures maximum purity.

Mushroom Blend Tincture

Important Details
Company: Ceremony Mushrooms
Key Components: The mushroom supplements contain Turkey Tail, Chaga, Lion’s Mane, Cordyceps, Shiitake Mushrooms, and Reishi mushroom extracts
Dosage: Take 2 ml one time a day
Guarantee: 30-day satisfaction guarantee
Starting Price: $59

Ceremony Mushrooms is more than just a company with the best medicinal mushroom supplements; it combines holistic nutrition and clinical research experts who have admired the effect of mushrooms and herbs on the body. This brand flourished into existence because of the lack of consistency in texture and taste. Having been established on the brink of COVID-19, things weren’t always smooth sailing, but fortunately, their mushroom supplements have since been well-received. One such solution is the Mushroom Blend Tincture, which might help nourish energy levels, boost mental clarity, and regulate the immune system.

Lion’s Mane

Important Details
Company: Circadian Wellness
Key Components: Lion’s mane mushroom extract
Dosage: NA
Guarantee: NA
Starting Price: $30

Circadian Wellness is a company that strongly believes that re-aligning the circadian rhythm using medicinal mushrooms and other best mushroom supplements is the solution to a healthy mind, body, and spirit. In this case, their take on Lion’s Mane Mushroom uses a licensed proprietary Quicksome technology reckoned to increase bioavailability at lower doses. That’s right, they aren’t so much for “the stronger, the better” ideology but instead would prefer to elevate the effects of even the smallest of doses. With the help of this mushroom supplement, individuals can anticipate holistic healing towards insomnia, focus and energy levels, exhaustion, and sexual dysfunction, to name a fraction.

Earth Nutri Performance Energy + Focus

Important Details
Company: Earth Nutri Performance
Key Components: Acetyl-L-Carnitine Hydrochloride (2000mg), L-Tyrosine (2000mg), Cordyceps, King Trumpet, Shiitake, Lion’s Mane, and Turkey Tail Mushrooms, and Reishi mushroom extracts
Dosage: Serve one stick per day
Guarantee: 30-day money-back guarantee
Starting Price: $39.98

Energy + Focus mushroom supplement is advertised as a mental performance enhancer that guarantees a sustainable energy source that will last an entire day. This mushroom supplement is formulated to improve energy levels and focus, recovery, and provide other health benefits. Earth Nutri Performance Energy + Focus contains a series of blends and patented ingredients needing analysis. But before we get into the contents of the Energy + Focus mushroom supplement, it is essential to note that this solution is for anyone in dire need of enhanced clarity, memory, concentration, and mood.

Mushroom Blend Mix

Important Details
Company: Four Sigmatic
Key Components: Each Mushroom Mix serving constitutes the likes of Chaga (150mg), Reishi mushroom extract (150mg), Cordyceps (150mg), Shiitake (150mg), and Maitake mushroom extracts
Dosage: Take two scoops (2g) per serving
Guarantee: 100% satisfaction guarantee
Starting Price: $30

The Mushroom Blend Mix is caffeine-free immune support that combines ten medicinal mushrooms. The Four Sigmatic team affirms that two scoops into a choice of either coffee, tea, smoothie, or soup suffice to elicit health benefits. 100% organic, plant-based and have undergone rigorous testing, and the team also made sure to elevate the taste. The taste of mushrooms is said to have been highly masked in whatever base. Playing with the statistical term “sigma,” which assesses how far an observation is from the average, this brand insists that their mushroom supplements are well beyond the standard three sigmas, making them “much, much, much, much better” than the average.


Important Details
Company: FreshCap
Key Components: Like most mushroom supplements, it has Lion’s Mane, Cordyceps, Reishi, and Maitake Mushrooms, Chaga, and Turkey Tail mushroom extracts
Dosage: Take two capsules two times a day
Guarantee: A complete happiness guarantee
Starting Price: $22.50

If one company truly has a long love for mushrooms, it is the lo and behold FreshCap. Every conceivable product found on their official website celebrates different singles and combinations of mushrooms. Founders Tony and Tegan have always been passionate about growing mushrooms and teaching others about them, and realizing the impact that real food has on natural health, respectively.

At present, FreshCap offers mushroom-infused drinks, mushroom powders, turkey tail capsules, and shroomies to account for various consumption preferences. We found it interesting that this brand is its commitment to educating consumers on the different layers of mushrooms and how they interact with the body.

Genius Mushrooms

Important Details
Company: The Genius Brand
Key Components: Each serving of Genius Mushrooms is said to deliver equal amounts of Organic Cordyceps (500mg), Organic Lion’s Mane, and Organic Reishi mushrooms
Dosage: Serve three capsules a day
Guarantee: 90-day satisfaction guarantee
Starting Price: $21.99

Genius Mushrooms offer three organic mushroom supplements that allegedly work in unison to enhance mental clarity, immune function and deliver a sustainable energy source. As a brand that flourished into existence because of a “passionate vision and industry realization,” The Genius Mushrooms Brand tries to deflect ongoing myths such as “your pre-workout must contain legal amphetamines for it to be effective” or “you have to drink BCAAs all day if you are serious about building muscle.” For those of you wondering how exactly this brand of Genius mushrooms deflects them, they do so by focusing on natural and high-quality alternatives while ensuring that Science remains at the core.

Supershroom Powder

Important Details
Company: Goldmine
Key Components: Astragalus (300mg), reishi fruiting body mushroom (300mg), Turkey Tail mushroom extract (200mg), and Maitake Mushrooms ( maitake fruiting body mushroom). Other included enticing tastes include Organic Lucuma Fruit and Organic Ginger Rhizome
Dosage: Take 1/2-1 tsp three times a day
Guarantee: NA
Starting Price: $28

Supershroom Powder is immunity support that combines the effects of four mushroom types and additional herbs for easy drinking. The Goldmine team attests this drink is nutrient-dense and packed with anti-inflammatory compounds called polysaccharides. These are low-calorie, low-cholesterol, and low-sodium combinations deemed effective enough at boosting exercise performance and stimulating white blood cell production (vital for fighting off free radicals).

With emphasis placed on accessibility, transparency in sourcing, and sourcing responsibility from USDA organic certified farms, Goldmine created Supershroom.

Mushroom Vitality

Important Details
Company: GundryMD
Key Components: Like other mushroom supplements in the list, the formula entails reishi mushroom fruiting body, Coriolus mushroom fruiting body, and Chaga mushroom mycelia, but unfortunately, the concentrations have not been disclosed
Dosage: Serve 4 ml a day
Guarantee: Money back guarantee of 90 days
Starting Price: $65.95

As maintained by the GundryMD team, Mushroom Vitality is a tincture constituting the “big three” mushrooms. The choice for mushrooms in this mushroom is trusted to provide the body with a synergistic blend of immune-boosting nutrients. That said, this one of the best mushroom supplements can either be consumed as a beverage mix or directly on the tongue. Nonetheless, consistent uses may support healthy immune function, induce feelings of freshness and renewal upon waking up and prevent free radical damage.


Important Details
Company: Dose Nomadic Nutrition
Key Components: The MindHoney formula contains Vitamin B3 (20mg), Vitamin B6 (5mg), Vitamin B12 (5mg), Vitamin B9 (400mcg), a 500mg-Proprietary Mushroom mix encompassing Lion’s Mane, Cordyceps, Reishi, and other proven mushroom extracts
Dosage: Serve two capsules a day
Guarantee: NA
Starting Price: $39.95

MindHoney is a dietary supplement with medicinal mushroom extracts, perceived as a suitable substitute for both energy- and cognitive-boosting goals. Individuals can anticipate a sustainable boost free from jitters and afternoon crashes by introducing the combined effects of adaptogenic herbs and medicinal mushrooms. Hence, just about anyone can benefit from the formula, whether entrepreneurs, athletes, students, travelers, or professionals. This is one of the best mushroom supplements on our list.

MUD\WTR Starter Kit

Important Details
Company: MUD\WTR
Key Components: The MUD\WTR formula contains Reishi (562mg) and Chaga mushroom extracts, Lion’s Mane (562mg), and Cordyceps mushroom extracts. Apart from mushroom extracts, it has Organic Cinnamon, Organic Turmeric, Organic Ginger, Organic Cardamom, Organic Black Pepper, Organic Nutmeg, Organic Cloves, Organic Black Tea, and Himalayan Pink Salt
Dosage: Take 6g daily
Guarantee: NA
Starting Price: $60

Starting the day with the MUD\WTR Starter Kit is reckoned to give rise to a productive day ahead. With an emphasis on a micro-dose of caffeine (1/7th of a standard cup) and a macro-dose of medicinal mushrooms and ayurvedic herbs, a mug a day is deemed more than enough. Inside each kit, individuals will find a 30-serving tin of “mud,” a USB rechargeable frother, and free stickers, a guidebook, and a sample of the MUD\WTR creamer. Though storytelling is minimal here, the team has since created an elaborate FAQ section expounding on all possible questions that consumers may have regarding mushroom extracts and the overall product.

Mushroom Defense

Important Details
Company: Leading Edge Health
Key Components: Each serving of Mushroom Defense delivers Cordyceps (266mg), Reishi (266mg), Shiitake (266mg), Lion’s Mane Mushrooms (266mg), and a 266mg-Proprietary Blend of Maitake mushroom extracts, Turkey Tail mushroom extract, Chaga, Royal Sun Agaricus, White Button, and Black Fungus Mushroom Extracts
Dosage: Take two capsules daily
Guarantee: 67-day satisfaction guarantee
Starting Price: $59.99

Mushroom Defense is an immune-boosting supplement encompassing neither one nor three but a total of 10 mushroom varieties so that results are attained on a cellular level. Aside from immune-stimulating possibilities, individuals can anticipate increased antioxidants delivery, focus, mental clarity, and sustainable energy levels with mushroom Defense. As more and more consumers find comfort in their processes, Leading Edge Health consistently reflects their values in their mushroom supplements like Mushroom Defense.

Mushroom Revival

Important Details
Company: Mushroom Revival
Key Components: The mushroom supplements have Lion’s Mane mushroom, Reishi mushroom, Cordyceps mushroom, and other proven mushroom extracts
Dosage: Take two squeezes of the dropper bulb on your tongue
Guarantee: A money-back guarantee of 90 days
Starting Price: $34.95

Mushroom Revival is a brand devoted to offering nothing but organic mushroom supplements. As stated in its name, the goal is to “revive health with functional mushrooms.” This approach has been used throughout history and, in recent times, has been scientifically proven. Like many of the best mushroom supplements on our list, they mostly started with energy deficiency and the gruesome consequences of excessive caffeine intake. Founder and CEO Alex Dorr of Mushroom Revival claims to have found maximum comfort in medicinal mushrooms and has since “committed himself to lead a healthier way of life.”

Alex’s passion for helping others only grew with every new insight gained, leading him to found Mushroom Revival. As a brand, all best mushroom supplements offered are promised to have undergone third-party lab testing (with transparent results) and contain USDA-organic certified, vegan, gluten-free, KOF-Kosher certified, and NSF-certified ingredients. Presently, Mushroom Revival carries four tinctures: Reishi Calm, Mushroom Mix Daily 10, Lion’s Mane Focus, and Cordyceps Energy. For people interested in the test results, a QR scan code has been included on every bottle.

MycoPhyto Complex

Important Details
Company: EcoNugenics
Key Components: The MycoPhyto Complex contains 3.84g of the MycoPhyto Proprietary Blend (Turkey Tail, Reishi, Agaricus, Cordyceps, Zhu ling, and Maitake) and Beta-1, 3-glucan (150mg)
Dosage: Serve six capsules daily
Guarantee: NA
Starting Price: $104.95

MycoPhyto Complex is officially the most priced and highly concentrated mushroom supplement that made our list. According to EcoNugenics, the goals for MycoPhyto Complex are to train and balance the immune system, enhance energy and stamina, provide support against infrequent cold symptoms, boost the metabolism, tend to cardiovascular and respiratory health, and ensure optimal cellular function.

Shroom Tech SPORT

Important Details
Company: Onnit
Key Components: On the topic of formula, each serving encompasses Vitamin B12 (750mcg), Chromium (200mcg), Shroom Tech O2 or Cordyceps (1.2g), and a 930mg-Shroom Tech Adaptogen Blend consisting of Ashwagandha, Green Tea Leaf Extract, Rhodiola, and Astragalus Root
Dosage: Take four capsules daily
Guarantee: 90-day satisfaction guarantee
Starting Price: $23.29

Shroom Tech SPORT is one of the best mushroom supplements. It has been designed with the hopes of increasing cellular energy and cardiovascular endurance. Hence, fitness fanatics and athletes can anticipate boosting their exercise volume and aerobic performance. Speaking of cellular energy, the Onnit team insists that the limitations imposed on the body’s capacity to produce ATP prevent consumers from reaching their best. This approach makes it one of the best mushroom supplements in the market. With Shroom Tech SPORT, the latter goal is deemed possible thanks to a series of mushrooms and herbs.


Important Details
Company: Organixx
Key Components: 7M+ fermented mushroom pills reflect a 700mg-Fermented Mushroom Mycelium Complex Blend of Turkey Tail, Chaga, Shiitake, Maitake, Cordyceps, Lion’s Mane, and Reishi Mushrooms along with a 240mg-Fermented Kelp Blend of Sprouted Purple Maize and Kelp extract
Dosage: Take two capsules daily
Guarantee: One-year money-back guarantee
Starting Price: $54.95

As maintained on the official website, 7M+ represents “centuries-old knowledge” on mushrooms combined with anti-aging nutrients for immune-supporting purposes. The name gives away that each serving constitutes seven organic mushroom varieties that deliver “infection-fighting compounds called “beta-glucans.” Consequently, this best mushroom supplement could provide antioxidants essential to prolong cellular aging while enhancing mood, digestion, and energy levels.

WonderDay Mushroom Gummies

Important Details
Company: Plant People
Key Components: Every gummy contains a 2500mg-Adaptogen Complex + Mood, Immune, Energy, Cardio, Gut Blend of Lion’s Mane, Cordyceps, Reishi, Chaga, Maitake, Turkey Tail, Shiitake, Wood Ear, White Button, and Royal Sun Mushrooms
Dosage: Serve two gummies daily
Guarantee: 100% satisfaction guarantee
Starting Price: $29.99

Unlike other mushroom supplements, WonderDay Mushroom is a dietary supplement in gummies forms offering ten functional mushrooms. Finally, a delivery system that is neither powder or capsules, right? Created in wild raspberry flavor, the WonderDay Mushroom Gummies are believed to modulate the body’s stress response, boost energy, mental and physical performance, promote healthy digestion, and strengthen the immune system. Besides different delivery, this best mushroom supplement has been doctor-formulated (with a practitioner advisory board in place).

Pure Essence MyPure Lion’s Mane

Important Details
Company: Pure Essence
Key Components: Organic Lion’s Mane Mushroom Extract
Dosage: Take one capsule
Guarantee: 90 days money-back guarantee
Starting Price: $23.22

MyPure Lion’s Mane is a mushroom supplement celebrating 500mg of premium, organic Lion’s Mane Mushroom per serving. As explained by the Pure Essence MyPure Lion’s Mane team, this mushroom has been a part of Traditional Chinese Medicine to support brain and neurological health. After some time, Lion’s Mane was discovered as equally helpful for the stomach and liver function (i.e., promoting healthy digestion), mood, cognitive function, and immune system.

Real Mushrooms

Important Details
Company: Real Mushrooms
Key Components: The mushroom supplements include (but are not limited to) Mushroom D2Z, Organic Lion’s Mane, 5 Defenders Organic Mushroom formula, Organic Cordyceps, Organic Reishi, Turkey Tail, Organic Siberian Chaga, Vitamin D from Organic Mushrooms, Organic Tremella, and Ergo+Ergothioneine
Dosage: Take 1/2 teaspoon per serving
Guarantee: NA
Starting Price: $29.95

Based in Canada, Real Mushrooms is not like other mushroom supplement companies. The brand offers a variety of medicinal mushroom powders like Mushroom Hot Chocolate Mix, 5 Defenders, etc. It is a family-owned and operated business with over 40 years of mushroom growing experience. The name “Real Mushrooms” was given to place emphasis on the fact that each of the mushroom supplements offered carries nothing but “real” mushrooms rather than the root system of mushrooms (i.e., also referred to as the mycelium on grain). With this knowledge, the team at Real Mushrooms decided to devote an entire line of mushroom supplements so that the public is as aware of the differences as the founder, Jeff Chilton, is.

Mushroom Extract Gummies

Important Details
Company: Shroomy
Key Components: Each gummy serving contains a “potent and meticulously tested” 300mg Mushroom Blend combining the likes of Lion’s Mane, Reishi, and Cordyceps
Dosage: Serve two gummies
Guarantee: NA
Starting Price: $29.99

Shroomy’s Mushroom Extract Gummies have been created to support brain and cognitive function (i.e., nootropic and mushroom formula). Unlike other mushroom supplements in the list, each serving contains three different mushrooms reckoned to clear brain fog and strengthen the immune system. Though we initially thought these gummies were brain-focused only, it should be evident that the trio may go as far as tending to different aspects of the mind, body, and soul. For now, there’s nothing available on the story behind Shroomy, which is disappointing, as transparency is one factor where Shroomy falls slightly under that most mushroom supplements in our list.

Focus Performance

Important Details
Company: Spore Life Sciences
Key Components: Each Focus Performance serving delivers Lion’s Mane (500mg) and Cordyceps mushroom extracts(400mg), Ashwagandha (200mg), and Ginkgo Biloba (160mg)
Dosage: Take three capsules daily
Guarantee: 30-day money-back guarantee
Starting Price: $44.95

One of the best mushroom supplements, Focus Performance, is cognitive support that delivers essential brain fuel through mushroom extracts and other elements for optimal performance. Spore Life Sciences landed on the collective effect of medicinal mushrooms and herbs to enhance cognitive function while balancing the mood to determine the best strategy. In turn, individuals can anticipate improved “working memory, expanded creativity and support for [the] brain’s neurological functioning.” At Spore Life Sciences, the goal is to bring researched and scientifically proven benefits to the table, evidently hinted at in the company’s name.

The Drug Store Adaptogenic Mushrooms

Important Details
Company: TheDrug.Store
Key Components: TheDrug.Store currently offers a few mushroom supplements that contain any combination of Chaga mushroom extract, Reishi and Lion’s Mane mushroom extracts, Shiitake, and Cordyceps Mushrooms in various delivery systems (i.e., mushroom powders, capsules, tinctures, etc.)
Dosage: Take ½ Tsp per serving
Guarantee: NA
Starting Price: 15 GBP

TheDrug.Store is founded on the ideology that “Wellness is personal.” More specifically, the co-founders insist that there’s no one size fits all approach. Realizing that many mushroom supplements are made that way, this company was established and continuously provides unique solutions while educating and building long-lasting relationships with customers. Actual mushroom supplements include Wunder Workshop, Glow Bar, Anatome, Apothem, Equi London, The Beauty Chef, Biocol Labs Something, Medterra, Indi, and KIKI Health, to list a few.


Important Details
Company: VidaCap
Key Components: Individuals have the option to choose out of mushroom supplements like Pure Mushrooms (i.e., Lion’s Mane, Turkey Tail, Reishi, Cordyceps, and Chaga) or Mushroom Blends (i.e., “Sleep,” which contains, Passionflower, Melatonin, and organic mushroom powder
Dosage: Take two capsules daily
Guarantee: The mushroom supplements come with a 30-day money-back guarantee
Starting Price: $24

Based in America, VidaCap specializes in developing medicinal mushroom supplements from all over the world. For instance, their source of Chaga is said to come from Russia, while every other variety was grown in China in closed greenhouses. To ensure the quality of mushroom supplements is up to par, the team considered skilled growers, responsible cultivation and harvesting processes, batch-by-batch testing, ethical measures, and in terms of mushrooms – whether they are fruiting bodies or mycelium (the only mycelium product being their cordyceps).

Adaptogen Recovery

Important Details
Company: Vital Plan
Key Components: Each serving of Adaptogen Recovery embodies the power of Chinese Skullcap (450mg), Cordyceps (450mg), Rehmannia (50mg), and Reishi mushroom extracts(175mg)
Dosage: Take three capsules daily
Guarantee: 90-day money-back guarantee
Starting Price: $72

Adaptogen Recovery is an herbal-inspired mushroom supplement intended to strengthen the immune system so that stressors of various kinds have little to no impact on the body. A facet that allows this brand to stand out is its B Corporation® certification (one that reflects high standards of social and environmental performance, and transparency among others), which only ten mushroom supplement companies worldwide have been provided with.

Brain Boost

Important Details
Company: Vital Plan
Key Components: Vital Plan team studied five clinical-grade herbs such as Lion’s Mane mushroom extract (500mg), Cat’s Claw (350mg), Bacopa Extract (300mg), Sensoril Ashwagandha (125mg), and Ginkgo Biloba Extract (120mg)
Dosage: Serve four capsules daily
Guarantee: 90 days money-back guarantee
Starting Price: $48

Another Vital Plan supplement to have made our list is Brain Boost. As hinted in its title, it may support memory and cognitive function, provide mental clarity and focus, ensure the immune and gut functions are maximized, and regulate mood and stress. We liked this supplement for its ability to promote results using ancient herbs and Vital Plan’s thorough breakdown of what each plant/herb does. Everything has been color-coordinated to help consumers connect the dots between the ingredients and the area of the body being recovered.

Immune Support

Important Details
Company: VitaPost
Key Components: Key Components: Vitamin C (30mg), Vitamin E (30IU), Selenium (20mg), Graviola Leaf (300mg), Raspberry (200mg), Green Tea Extract (200mg), Turmeric (100mg), Mushroom Complex (80mg of Shiitake, Reishi, and Maitake), and other mushroom extracts
Dosage: Serve two capsules
Guarantee: NA
Starting Price: $13.95

The mushroom complex of VitaPost Immune Support has been formulated to deliver everyday nutritional support in herbal extracts and a broad spectrum of antioxidants. Given that our immune system is constantly in battles against pathogens and diseases of different strengths, a supplement like Immune Support can help fortify and recharge it. VitaPost takes pride in introducing thousands of years of wellness practices that meet scientific standards regarding the strategy employed in its mushroom supplements.

Magic Mushroom

Important Details
Company: YourSuper.com
Key Components: Magic Mushroom powder contains Cacao (Peru), Chaga mushroom extract (China), Ashwagandha (India), Reishi mushroom extract(China), Lucuma (Peru), and Cinnamon (India)
Dosage: Take 5g in a single serving
Guarantee: 30-day money-back guarantee
Starting Price: $34.90

Finally, we have one of the best mushroom supplement companies, YourSuper.com. Its Magic Mushroom, which, believe it or not, is a hot chocolate powder mixed with mushroom extracts. Made using only six organic ingredients, magic mushroom supports and strengthens the immune system while helping the body better respond to stressors of all kinds. This is one of the preferred mushroom supplements. Co-Founder Michael was diagnosed with cancer and had to learn to rebuild his immune system. To help with his recovery, co-founder Kristel shared all her homemade mixes of superfood powders, which were initially developed to help with her mom’s health. Given the evident importance of the immune system and every other body component, the duo decided to share their journeys with the entire world via YourSuper.com.

The Guiding Framework: How The Above Mushroom Supplements Made Our List

Typically, consumers tend to choose mushroom supplement companies based on reviews. The more stars, the better, right? There are two things wrong with this. First, reviews can be fabricated to make a mushroom supplement look and sound effects. Second, regardless of whether the reviews are good or bad, we generally wouldn’t know if a consumer was consistent for at least three months before assessing the results. This is not to say that examining customer reviews to rate a mushroom supplement is wrong, but more so that it might not be enough.

In the meantime, here’s what we sought for:

Company & Transparency

Unfortunately, transparency is typically overlooked when selecting mushroom supplements. This shouldn’t be the case since it represents a source of ingredients, supplement fact, growing and manufacturing processes, a company’s knowledge of the market, lab testing (and sharing results), etc. Without substantial background on either the company or level of transparency, looking at any other features becomes meaningless. If mushroom supplement companies choose to mask themselves, why should we consider its mushroom supplement first?

Scientific Evidence & Effective Dosing

Many of the mushroom varieties we noticed in the above list of best mushroom supplements have some scientific evidence, whether preliminary or advanced. Some mushroom supplement companies appear to have tested their solutions in clinical studies, which is ideal.

Types of Mushrooms

There are several mushroom varieties available on our very earth that are used in mushroom supplements. Some of them are functional/medicinal mushrooms, whereas others are strictly for culinary purposes. Our goal as a team was to bring to light helpful mushroom supplements, and we believe we’ve achieved exactly that.

Supporting Ingredients

Some best mushroom supplements decided to include supporting ingredients in vitamins, minerals, plants, herbs, antioxidants, caffeine, etc. Hence, we encourage consumers to take the time to do their due diligence before settling on a specific mushroom supplement.

Value for Price

Finally comes value for the price, which is determined after seeing how many boxes of mushroom supplements within our guiding framework have been checked off. As a rule, we can’t expect a company to pour in their time, money, and effort to gain a small monetary benefit. At the same time, we shouldn’t appreciate a company that does so little yet expects a big piece of the pie!

What Story Does Science Tell Regarding the Effects of Mushrooms on the Body?

A list of health benefits for each mushroom variety doesn’t suffice (at least not in today’s day and age). While society has the utmost respect for ancient traditional medicines, we’ve evolved to a point where some alignment between tradition and Science needs to be established. To what extent does the latter hold regarding medicinal mushrooms? We are about to find out, below is an introduction to the scientific narrative surrounding mushrooms:

Lion’s Mane

According to Cognitive Vitality, lion’s mane has some evidence suggesting that it could improve cognitive function in healthy consumers or those with mild cognitive impairment (MCI). As for its role in the body, the ingestion of Lion’s Mane has increased nerve growth factor (NGF) levels, as it increases the length of nerve cell processes. Moreover, two commonly known brain cell productions, i.e., hericenones and erinacines, heightened as well [11].


In 2018, the same team that studied the effects of cordyceps on the brain and succeeded in showing that it could improve learning and memory conducted another study emphasizing the actual mechanism. During this process, mice were allegedly given scopolamine hydrobromide to establish a mouse model of learning and memory impairment. In the end, the team confirmed that three genes were involved in such results (i.e., Pik3r5, Il-1b, and Slc18a2). In other words, cordyceps work by “scavenging oxygen free radicals, preventing oxidative damage, and protecting the nervous system. [12]”


A 2011 study was conducted to evaluate in vitro anticancer activity of Chaga, namely, its effect on the cell proliferation, motility, and viability of cancer and normal cells. In so doing, the researchers discovered that “Chaga fraction elicited anticancer effects which were attributed to decreased tumor cell proliferation, motility, and morphological changes,” further noting that future studies may lead to promising results [14].

Turkey Tail

2019 in vitro study aimed to evaluate the immune-regulating properties of turkey tail in two forms: mycelium versus the fermented substrate. In the end, it was mycelium that prevailed, as it demonstrated the “immune-activating bioactivity of a mycelial-based medicinal mushroom preparation.” It was then argued that such a source contains a rich source of beta-glucans and water-soluble components, which could have helped achieve its effects [16]. Polysaccharide K (PSK) is deemed the best-known active compound in this medicinal mushroom extract. PSK remains an approved adjuvant treatment for cancer in Japan, as animal and human studies regarding gastric, breast, colorectal, and lung cancers led to promising results [17].


A 2011 study that looked at the effects of shiitake mushroom on obesity markers gave rats low, medium, and high shiitake mushroom powders and their high-fat diets for six weeks. In the end, the rats on high powder concentration and fat diet had the lowest body weight gain compared to both medium and low concentrations. In addition, plasma triacylglycerol (TAG) levels significantly dropped as well, allowing the team to conclude that dietary shiitake mushrooms may prevent fat deposition and lower triglycerides when paired with a high-fat diet [18].


HealthLine summarized existing research on Reishi and listed six potential health benefits of taking Reishi. Despite the uncertainty surrounding test-tube studies, it was reported that this mushroom variety could affect genes within our white blood cells, which are essential for immune function. It was also noted that Reishi might go as far as altering inflammation pathways as well. On the topic of the immune system, it is believed that improvements imply bettered mental health symptoms, particularly fatigue and depression. Reishi can kill cancer cells and benefit those with prostate cancer because of its effect on testosterone. Other possible health benefits include improved heart health, regulated blood sugar levels, and healthy antioxidant status [20].


Maitake has been shown to elicit immunomodulatory effects in preclinical studies where mice were subjects. Instead of mice, a 2019 study looked at the oral administration (0.1, 0.5, 1.5, 3, or 5mg/kg twice daily for three weeks) of Maitake in 34 postmenopausal breast cancer patients. Consequently, it was discovered that oral administration established an association between “immunologically stimulatory and inhibitory measurable effects in peripheral blood,” however, it was also highlighted that botanical agents of this nature might depress while enhancing immune function [21].

Ultimately, we hope that individuals reflect on the pros and cons before proceeding. Most importantly, the above scientific narrative is a glimpse into what has been done. Therefore, individuals will have to do their due diligence (in considering their health as a factor) before settling on a mushroom supplement of choice.

Frequently Asked Questions About Medicinal Mushrooms

Q: What mushroom varieties are popularly used in mushroom supplements?

A: Among the thousands that exist on our very earth, the most used varieties of mushroom supplements include Shiitake, Maitake, Reishi, Chaga, turkey tail, lion’s mane, and cordyceps. The reason for this rests in the fact that these strains have been of interest within the scientific community.

Q: Would medicinal mushrooms be considered a superfood?

A: Yes, researchers generally see medicinal mushroom extracts and mushrooms as a superfood because they are low in almost all the harmful components and carry a significant number of amino acids, antioxidants, and other valuable nutrients.

Q: How do medicinal mushrooms differ from the culinary types?

A: Medicinal mushrooms are generally more bitter than the culinary types, and due to consumers’ lack of knowledge on functional mushrooms, they are rarely considered. Fortunately, the mushroom supplements industry has helped fill in the voids in consumer knowledge, as seen in our top picks for 2021.

Q: Is there a specific timeframe in which mushrooms elicit the best results?

A: No, medicinal mushrooms and mushroom supplements elicit the same results regardless of when they are ingested.

Q: Are there side effects to taking medicinal mushrooms?

A: Yes, but it comes down to one’s health, medication intake, and medical history. For a healthy person, the side effects of medicinal mushroom supplements are very scarce, if not camouflaged. Therefore, we always encourage the combination of research and discussions with health practitioners before implementing mushroom supplements into one’s routine.

Q: Are medicinal mushrooms hallucinogenic?

A: No, at least not the mushroom supplements recommended in our top picks. Magic mushrooms can elicit a hallucinogenic experience because of their dominating compound called psilocybin.

Q: What are magic mushrooms?

There are various types of mushrooms and mushroom blends companies use these days; magic mushrooms are one of those. The magic mushrooms are rich in psilocybin which takes care of mood and cognitive processes in humans.

Q: Are medicinal mushrooms beneficial?

A: They can be helpful under the right conditions (i.e., consistency in administering serving sizes and doses). At least, that’s what researchers are declaring based on existing preliminary results.

Q: Can medicinal mushrooms be taken alongside prescription medications?

A: Yes, medicinal mushrooms can be taken alongside prescription medications. However, this is a discussion with one’s respective health practitioners, as certain medications may interfere with mushrooms’ properties. For instance, it has been found that high doses of reishi mushroom extract might slow blood clotting and increase the chances of bruising and bleeding [28].

The Top Medicinal Mushroom Supplements of 2021 Final Verdict

Ultimately, mushrooms and mushroom supplements appear to carry value when it comes to different areas of the body. Based on preclinical studies, certain varieties can support our immune system, energy production, brain health, brain health, and mental health.

Nevertheless, ingesting mushrooms can be tricky if the right mushroom supplements aren’t selected. As seen in medicinal mushroom formulas above, the process of elimination is no small feat, as a guiding framework had first to be employed to decipher a solid and helpful solution from a possibly weak and useless one. Of course, this ranking system of sorts can be altered according to one’s needs, wants, and health conditions, which we are actively encouraging. The 29 supplements that made the cut have satisfied the basic requirements for utmost wellness. It is important to stress that wherever clarity is missing, we want people to go out of their way to ask appropriate questions because one’s health must be of immense priority at the end of the day.

Until we revisit medicinal mushroom supplements, we hope that everyone is content with the process laid out in this guide. Forget buying something based on popularity, as quality protection usually comes from rigorous analysis, which should be conducted for anything new!

RELATED:Best Immunity Boosters – Top Immune System Supplements

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