Flexotone Reviews: Negative Side Effects?

In a recent presentation, Dr. Ernest Pramza vows “undeniable scientific evidence” that can free consumers from joint, back, arms, and/or legs pain altogether. He is not suggesting topical creams or prescription medications but instead a dietary supplement that holds the alleged hidden truth regarding recovery. Literally, the recommended solution is trusted to get to the bottom of the root cause rather than providing temporary relief. If any of this piqued your curiosity, our editorial team is on your side! To see what makes Dr. Ernest Pramza’s formula matchless compared to industry standards, this review has been put together to analyze the newly launched “Flexotone thoroughly.”

What is Flexotone?

Flexotone is a dietary supplement that rejoices the combined effects of 18 all-natural ingredients reckoned to destroy bacteria and rejuvenate joints within weeks. This could mean good riddance to muscle stiffness and reduced range of motion and inflammation, among other known symptoms. As Dr. Ernest Pramza, the root source of pain isn’t the joints but the gut. How is this possible? In what way(s) are joint pain and bacteria presence related? To get clarity, individuals will first need to understand the Flexotone mechanism.

How does Flexotone work?

Flexotone has been formulated to target a bad bacteria in the gut called Prevotella copri, deemed the root cause for joint pain. One study that looked at the effect of Prevotellaceae on patients with rheumatoid arthritis (RA) concluded that intestinal dysbiosis might have a role in the development of RA [1].

For people who are unversed with “dysbiosis,” there is an imbalance of bacteria within the stomach and intestines. Consequently, this might result in low-grade systemic inflammation, negatively impacting musculoskeletal health. Since this is a relatively new finding, more studies are sorely needed [2]. However, the scientific community is convinced that this possible reason can open doors to new opportunities filled with healing.

Using this knowledge, Dr. Pramza paired up with Dr. Mehok to develop Flexotone to eliminate and protect the body from the likes of Prevotella copri. Specifically, five steps were of interest, which is listed as:

Repairing the gut lining, as this is the point at which bacteria enters the bloodstream, and eventually impacts the joints

In so doing, the strength of bacteria will decrease, allowing joint tissues to commence natural healing and reparation processes.

Introducing ingredients that rejuvenate the joints for maximum flexibility

Providing additional nutrients that shield the joints and bones against future pain

Within a few weeks, the range of motion will increase while protecting the immune system

What ingredients are inside Flexotone?

Flexotone contains 18 all-natural ingredients. Below is a brief explanation of the characteristics and possible benefits of each one:


Thiamine (also known as vitamin B1) is mainly responsible for inducing the body to use up carbohydrates for energy and promoting glucose metabolism. One source noted that people with a thiamine deficiency are likely to experience low stomach acid because the body is incapable of releasing hydrochloric acid from gastric cells. In succession, the gastrointestinal tract is said to deteriorate, yielding unwanted symptoms such as nausea, GERD, and bloating, to say the least [3]. The latter issues are significant because such conditions increase holes in the gut lining through which bacteria might enter the bloodstream.


Niacin or vitamin B3 has been studied in terms of its effects on osteoarthritis in an outdated pilot study. 72 patients were split between a control (Vitamin B3) and placebo group. In the end, the researchers found that though pain levels did not alter much, those on vitamin B3 experienced reduced anti-inflammatory medications intake by 13% and witnessed an increase in joint mobility by 4.5 degrees over controls. This permitted the team to suggest niacin as a possible treatment [4].


Folate or vitamin B9, like vitamin B3, is favored to provide some relief for people with osteoarthritis (i.e., in terms of improving joint mobility and handgrip). However, the exact mechanism through which such benefits are possible supposedly remains unknown. For now, evaluations have been made based on vitamin deficiencies only [5].

Euterpe Oleracea

Also referred to as the acai palm (housing acai berries), Euterpe oleracea may play a role in reducing inflammation because of its rich source of antioxidants. In fact, one study that evaluated the role of acai pulps on pain and range of motion concluded that pain was significantly reduced and range of motion improved. The best correlation, as per the researchers, was between wellness and antioxidant status [6].

Vitamin B6, Vitamin B12 & Vitamin B7

Both vitamin B6 and vitamin B12, along with other B vitamins (including B7), are supposedly involved in multiple processes related to muscle function. One study investigating the association between niacin, vitamins B6 and B12, and folate concluded that vitamin B6 had been primarily linked to increased handgrip strength and mild physical performance [7].


Magnesium is a mineral accountable for over 300 functions in the body, one of them being bone and muscles health. Interestingly, one written work noted that the mineral has increased flexibility and may help prevent injury by loosening tight muscles. A magnesium deficiency might increase lactic acid, a component known to cause pain and tightness after a workout [8].

Pantothenic Acid

The next B-vitamin to have cut is vitamin B5, which has been tasked with producing blood cells and helping convert food into usable energy. Regarding its ingestion, one-piece explained that it could protect bones against estrogen deficiency, adding that dietary supplementation may perhaps reverse ovariectomized (OVX) induced bone loss [9].


L-taurine is an amino acid believed to help manage osteoporosis in ovariectomized rats. Specifically, a study that investigated this relationship concluded that taurine supplements exhibited healthy bone biochemical markers while also increasing bone mineral density and bone mineral content [10].

Spirulina Algae

Spirulina is a type of blue-green algae that carries an antioxidant-rich profile. Matter-of-factly, it is reasoned as having strengthening capacities on immune cells called natural killer (NK) cells. NK cells are the ones to detect and attack any perceived threat within our very cells; hence it makes sense to ensure their wellness. Other potential benefits that stem from ingesting these algae include (but are not limited to) prolonged tumor growth, protection against future illnesses, and a reduction in inflammation biomarkers [11].

Eurycoma Longifolia

Eurycoma longifolia is a shrub whose root and bark are used for medicinal purposes. One study that looked at the effect that ingesting EL (200mg/day) had on middle-aged men, and women found that EL did in fact exhibit “comprehensive immunity” in both parties, further suggesting that “no severe adverse events were observed [12].”


Ginseng is a broad term that encapsulates 11 different plant varieties with fleshy roots that can elicit an array of benefits. Though it is unclear which type is found in Flexotone, one study that analyzed the effects of Panax ginseng highlighted its ability to regulate natural killer (NK) cells, dendritic cells, T cells, and B cells. Moreover, it might have better control over “inflammatory diseases and microbial infections [13].”


Also referred to as the Peruvian ginseng, Maca has traditionally been used to regulate hormone imbalances, sexual dysfunction, depression, and erectile dysfunction [14]. Unlike the above three ingredients, maca does not directly impact the immune system but can be viewed as a supporting component to accelerate it [15].

Frequently Asked Questions (FAQS)

Is Flexotone safe to take?

Flexotone is generally deemed safe to take because it is largely composed of vitamins, followed by a handful of amino acids, plants, and herbs. In addition, it is advertised as having undergone testing and abiding by the manufacturing guidelines imposed by the FDA. However, we have yet to see a supplement’s fact suggesting safe concentrations, and so, individuals are asked to contact customer service before placing an order.

What is the recommended serving size for Flexotone?

The recommended serving size is one capsule daily with either a glass of water or the biggest meal of the day.

How many Flexotone bottles are needed to see results?

3 Flexotone bottles are designed to stop inflammation on a cellular level and may help regain mobility in the knees, hands, and fingers. That said, it is ideal to continue it for a total of six months so that maximum protection is attained against inflammation-causing bacteria.

What if Flexotone doesn’t work as suggested?

Each Flexotone bottle has been protected by a risk-free, 60-day money-back guarantee. Hence, individuals have slightly under two months to decide whether Flexotone is a keeper. If not, customer service can be contacted for a full purchase price refund. Below is a summary of contact information that will facilitate the refund processes:

Email: support@flexotone.com

Return Address: 37 Inverness Drive E Ste 100 Englewood, CO 80112

How much does Flexotone cost?

Each Flexotone bottle has been manufactured to include 30 capsules enough for a month’s use. Since both Dr. Pramza and Dr. Mehok recommend long term uses, the following price’s breakdown might be of interest:

  • 1 Flexotone bottle: $69 each + a small S&H fee
  • 3 Flexotone bottles: $59 each + free S&H
  • 6 Flexotone bottles: $49 each + free S&H

The best way to buy Flexotone is to purchase the product directly from the official website and avoid ordering from third-party websites such as Amazon and eBay.

Meet Dr. Ernest Pramza

Dr. Ernest Pramza is a former physician responsible for the Flexotone formula. His decision to execute this solution stems from his years of experience in an unnamed pharmaceutical company. As part of his role, he, alongside his team, has been asked to research ways to increase the effectiveness of pain medications in severe cases of chronic arthritis and inflammation. Realizing how ill-minded his employer was, especially with his mind on just the money and urge to deliver nothing but addictive components, Dr. Pramza claims to have quit his job to conduct his respective research.

As he embarked on his journey towards a natural approach to healing, he crossed paths with Dr. Mehok, and the discovery that the duo made redefined how joint health was perceived. It turns out that pain doesn’t root in the joints, but in actuality, the gut. Specifically, the duo found that a bacteria called Prevotella copri was commonly found among those with joint pain. How did these bacteria take form? In the end, taking prescription drugs was believed to trigger bad bacteria, and once delivered through the bloodstream, they were affecting the joints. To bring an end to Prevotella copri, the duo landed at what’s known today as Flexotone.

Final Verdict

Based on the analysis above, Flexotone is a joint support supplement that aims to strengthen the gut lining so that bacteria like Prevotella copri do not penetrate through the walls. Otherwise, the chances of toxins entering the bloodstream and causing damage to the joints are high. The idea that alterations in the gut microbiome can give rise to joint aches is not new; in fact, some studies have linked bacteria to different varieties of arthritis. Hence, the arguments made by doctor duo, Pramza, and Mehok seem legitimate. Additionally, the ingredients found in this formula have supporting evidence as well.

Unfortunately, at the time of writing, information on the manufacturing company and the supplement facts have been omitted. The absence of such detail prevents our editorial team from confirming the legitimacy of this supplement, its effectiveness, and whether the formula is truly safe. For now, only 14 ingredients are known, which is slightly under the suggested 18. Above all, we were unsuccessful at validating Dr. Pramza’s and Dr. Mehok’s credentials, yet another cause for concern. For these reasons, we ask everyone to contact customer service for more clarity before placing an order. To learn more about Flexotone and how it might help reverse and protect consumers against joint pain, click here>>>.


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