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Best Immunity Boosters (2021) Top Immune System Supplements

The immune system plays a vital role in determining the quality of one’s health. It should be perceived as our savior because of its ability to barricade harmful substances, germs, and cell alterations among others. Think of it as a bubble encompassing various organs, cells, and proteins that need detailed protection to operate smoothly. Its significance is rarely thought of, unless of course, the bubble of wellness pops, and unfortunately, something so simple in any form, shape, and size can destroy things for everyone.

Besides improving upon one’s lifestyle choices, it might be a good idea to consider supplements that provide the added protection that our immune system needs to continue its operations as the ultimate savior. Having said that, the supplement industry is quite saturated, and our editorial team has decided, after immense research, to narrow the list down to 13 options. The purpose of this guide is to educate consumers on immunity-boosting supplements, supporting ingredients, factors to watch out for, and wellness altogether. Let’s get started with our picks of the best immune support supplements of the year!

Our Picks for a Complete Body Immunity

In no particular order or standing, listed below are our picks for a complete body immunity:

  • Advanced Bionutritionals Resistol
  • Doctor G’s Naturals’ Q-ION Immune Defen]]
  • Immunity Formulas Immune Support
  • JayLab Pro’s Immuno Defense 4X
  • Mushroom Defense
  • Organixx’ 7M+
  • PhytAge Laboratories’ Immunity 911
  • Simple Promise’s Epishield Plus
  • Sun Coast Sciences’ BioShield MD
  • VitaPost’s Immune Support
  • VitaPost’s Immune Complex
  • VitaPost’s Turmeric & Ginger
  • Zenith Labs’ Nano C

Advanced Bionutritionals Resistol

Starting Price: $29.95

Resistol was formulated with immune health in mind. As a provider of a cutting-edge line of nutraceuticals, Advanced Bionutritionals® affirms to have taken the scientific approach, which involves including evidence-backed ingredients only. Specifically, the team considered the likes of Andrographis (250mg), Platycodon (150mg), Eleuthero (120mg), Prickly Chaff Flower (150mg), and Licorice (75mg) per serving.

Together, these ingredients are said to not only support immune health, but also that of the lymphatic and respiratory systems, healthy inflammatory responses, and strengthened lung function. By briefly analyzing these ingredients, individuals are likely to realize that Advanced Bionutritionals® does not restrict themselves to industry standards and are willing to explore other safe and effective alternatives. Who can forget their “simple is sweet philosophy”?

Doctor G’s Naturals’ Q-ION Immune Defense

Starting Price: $47.94

As a doctor-formulated solution, the Q-ION Immune Defense is an embodiment of a new, science-backed method that is trusted to support immunity and provide unique strategies for utmost wellness. According to Dr. John Gordon, M.D., and Founder (or Doctor G for short), the use of the ION-blast technology ensures two things. First, it readjusts pH levels of endosomes (i.e., a primary intracellular organelle that regulates proteins and lipids), ensuring that pathogens are barricaded altogether. Second, some of nature’s potent immunity boosters were added to further block enzymes responsible for pathogen replication.

With time, individuals will watch symptoms including sinus and nasal infections, fatigue, brain fog, and pain disappear, helping everyone return to their best selves. That said, the ingredients responsible for such benefits include Zinc (11mg), Quercetin Dihydrate (500mg), Bromelain (125mg), and Green Tea Extract (30mg).

Immunity Formulas Immune Support

Starting Price: $64.99

What initially drew us to Immunity Formulas™ Immune Support is that it delivers herbal essential oils as a means of enhancing the immune system. That’s not the best part, interestingly, this solution is actually topical and the reason for this rests in the mere fact that airborne toxins and free radicals first encounter the largest part of our bodies, i.e., the skin. Matter-of-factly, it can also be used on surfaces or in a diffuser to completely rid one’s surroundings of said components.

Regarding the ingredients that made the cut, they include Lemon, Oregano, Peppermint, Cinnamon, Turmeric, and BioPerine. Though these ingredients carry significant scientific backing individually, the one area that we are uneasy with is the lack of a supplement’s fact, which would have heightened our confidence in terms of effectiveness and value for the price.

JayLab Pro’s Immuno Defense 4X

Starting Price: $44.95

Created by JayLab Pro, Immuno Defense 4X is described as a patented blend of immune-boosting nutrients that help to activate the body’s immunity for the ultimate combat against viruses and/or pathogenic bacteria. Another simple formula to have made the cut, the ingredients found per serving include a postbiotic called EpiCor® (500mg), Quercetin (500mg), Bromelain (150mg), and Vitamin D3 (1000IU).

Together, these ingredients are believed to support a healthy immune system, strengthen innate and adaptive immunities, and maximize the mucosal immune barrier. These are possible because of the formula’s ability to increase the secretion of immunoglobulin A (IgA) antibodies. To our surprise, the team has gone as far as clinically testing the formula, only to have discovered that it can activate the natural killer cell activity within a matter of two hours. As a final touch, Immuno Defense 4X is said to offer a protective layer for our cells while enhancing gut health.

Mushroom Defense

Starting Price: $29.99

As the name suggests, Mushroom Defense is a dietary supplement that encompasses nothing but mushroom varieties to enhance the immune system. In general, mushrooms are packed with vitamins, alkaloids, flavonoids, and phenolic compounds essential for neutralizing free radicals. Consequently, individuals can anticipate support in terms of health and longevity. The latter two factors can be achieved thanks to this formula’s rapid defense response, high antioxidant levels, the ability to help with focus and mental clarity, supercharging capacities for our natural killer cells, healthy blood flow, and increased energy levels to say the least.

The benefits are sure to impress many and to think that not one, but 10 mushroom varieties had to be considered is astonishing. Particularly, they include Cordyceps Sinensis Powder (266mg), Shiitake Mushroom (266mg), Lion’s Mane (266mg), Reishi Mushroom (266mg), and a proprietary blend (266mg) consisting of Maitake Mushroom, Turkey Tail, Chaga Mushroom, White Button Mushroom, and Black Fungus.

Organixx’ 7M+

Starting Price: $54.95

Following suit is another mushroom-focused supplement called 7M+. According to Organixx, 7M+ reflects centuries-old practice involving the medicinal uses of mushrooms that carry anti-aging and immune-supporting benefits. The “7” in its name hints at the number of mushroom varieties that have been selected. The latter process involved seeking clinical evidence, and infection-fighting compounds called beta-glucans. A feature unique to this supplement is the fermented nature of the included mushrooms, which as per the team, ensures maximum nutrition and bioavailability, along with the addition of kelp for a healthy liver function.

Regarding the formula itself, all the ingredients are organic and have been split between two proprietary blends. The first called the fermented mushroom mycelium complex blend (700mg) includes Turkey Tail Mushroom, Chaga Mushroom, Shiitake Mushroom, Maitake Mushroom, Cordyceps, Lion’s Mane Mushroom, and Reishi Mushroom. As for the second blend, it constitutes sprouted purple maize and kelp (240mg).

PhytAge Laboratories’ Immunity 911

Starting Price: $69.95

Compared to all the products we’ve discussed so far, PhytAge Laboratories’ approach in developing Immunity 911 involves multiple perspectives. Specifically, the team selected over 20 natural ingredients they believe work well together to build the body’s line of defense and to boost its ability to protect itself and its several cells, organs, and connections against diseases and viruses. With time, the included ingredients are believed to reduce stress, chronic and mental fatigue, and pain.

To our surprise, this extensive formula might also go as far as improving memory, vision, energy levels, and sleep quality. Finally comes the constituents of the formula, which entail Vitamin C (30mg), Vitamin E (20mg), Selenium (20mcg), and a proprietary blend (1512mg) of Graviola, Red Raspberry, Green Tea, Beta-Glucan, Turmeric, Pine Bark, Essiac Tea Complex, Grape Seed, Mushroom Complex, Quercetin Dihydrate, Pomegranate, Olive Leaf, Arabinogalactan, Cat’s Claw, Garlic, Panax Ginseng, and Lycopene.

Simple Promise’s Epishield Plus

Starting Price: $49

Epishield Plus is a dietary supplement that supports a healthy immune system, aids in respiratory and sinus health, and is trusted to enhance both the gut and digestive systems. As the name suggests, this formula is intended to build a shield surrounding gut health, which in turn is believed to give rise to several properly functioning cells, organs, and systems.

At the time of writing, the formula is said to encompass the likes of Vitamin C (500mg), Vitamin D (25mcg), EpiCor® (500mg), and Shiitake Mushroom (25mg), Cordyceps (25mg), Reishi Mushroom (25mg), and Maitake Mushroom (25mg). These are believed to work together to increase levels of the renowned mucosal antibody secretion of immunoglobulin A. Presently, Simple Promise is not offering this solution given the high demand for it and limited supplies. We encourage everyone to be on the lookout for updates from Simple Promise.

Sun Coast Sciences’ BioShield MD

Starting Price: $49.95

BioShield MD™ is a dietary supplement that is intended to support the body’s natural defense system, all while increasing energy levels, sharpening the mind, and easing overworked joints. Specifically, Sun Coast Sciences believes that their solution can help to balance cytokine response (i.e., risky proteins that damage organs and tissues), prevent the activation of microglia (i.e., brain fog driver), promote new collagen production, and increase gut health.

Designed with care by Dr. Mark Rosenberg, this formula contains Vitamin C (300mg), Vitamin D (37.5mcg), Zinc (5.5mg), CherryPURE (480mg), Turmeric Root Extract (100mg), Boswellia Serrata Resin Extract (100mg), Green Tea Extract (90mg), Polygonum Cuspidatum Root Extract (25mg) and Cocoa Seed Extract (20mg).

VitaPost’s Immune Support

Starting Price: $28.95

VitaPost is similar to PhytAge Laboratories in the sense that the company focuses on extensive approaches rather than sticking to simplicity (at least in this case). Based on the description provided, it is vital to combine over 20 ingredients to ensure immune support, healthy cellular processes, and antioxidants essential for combatting harmful toxins and bacteria among others. Regarding ingredients, they include Vitamin C, Vitamin E, Selenium, Graviola Leaf Powder, Raspberry, Green Tea, Turmeric, Beta-Glucans, Cat’s Claw, Garlic Bulb, Panax Ginseng, Lycopene, Quercetin, Pine Bark, Grapeseed, Pomegranate, Essiac Complex, Mushroom Complex, Arabinogalactan, and Olive Leaf.

VitaPost’s Immune Complex

Starting Price: $11.95

The second VitaPost product to have made the list is a humbler take on the aforementioned Immune Support. But this time the team appears to have considered a multi-layered approach to nutrition, which in turn is reckoned to enhance the immune and gut systems. To achieve immunity, this formula offers complete antioxidant support and nothing more. In fact, nutrients themselves range from flavonoids and polyphenolics to anthocyanins, curcuminoids, and alkamides. These can be obtained through Immune Complex’s included Vitamin C (180mg), Vitamin E (20mg), Vitamin B6 (3.4mg), Zinc (16mg), L-Glutamine HCL (200mg), Elderberry Fruit Extract (300mg), Echinacea Powder (200mg), Garlic Powder (100mg), Turmeric (100mg) and Lactobacillus Acidophilus (4.8 billion CFU).

VitaPost’s Turmeric & Ginger

Starting Price: $27.95

The final VitaPost product that took the internet by storm was the Turmeric & Ginger supplement. In recent times, Turmeric (550mg) has garnered a lot of attention for its powerful antioxidant benefits thanks to its main constituent, curcumin. Based on what we have gathered from the scientific community, its anti-inflammatory and antioxidant properties are what permit individuals to overcome chronic pain, starting with that felt in the joints. To add to this, Ginger (100mg) was considered because of its ability to promote digestive comfort and a healthy immune system. As a final touch, BioPerine (5mg) was included for the mere purpose of encouraging the body to absorb the curcumin compound.

Zenith Labs’ Nano C

Starting Price: $49

Nano C is a vitamin C supplement that delivers a version of the antioxidant that is 1000 times smaller than its original size. This has been done to guarantee that the body fully reaps the benefits of the most potent and widely recognized antioxidant in the market. Fortunately, the use of nanotechnology is said to deliver Vitamin C (500mg) straight to the bloodstream to fuel immune cells. As a result, the body will be forever grateful because of high levels of antibody production crucial for speedy recovery and protection from viruses and bacterial infections, and a healthy respiratory function.

The Ranking Criteria for the Top Immune Boosting Supplements

To learn more about all the immune boosting formulas listed in this article, visit the official supplement website for more information:

Undoubtedly, immunity boosters aren’t all made equally. Among the companies that want to make a positive impact on consumer wellness, there is a handful that simply takes advantage of the need for immunity support. Since consumer wellness is at stake here, we couldn’t just list any supplement that came our way. And so, we decided, if our picks met the following requirements, then they are likely to be effective:

Scientifically Backed Ingredients

With any supplement, the ingredient list should be thoroughly investigated. While the idea of ingesting natural ingredients might sound comforting, there needs to be positive evidence for its uses, otherwise, they become unnecessary spending. Bear in mind that our editorial team spent time going over the supplement’s facts to ensure that at least 80 to 90 percent of ingredients have either preliminary findings or ideally, strong claims with repeated studies. If an ingredient embodies a balance between traditional uses and science, it was definitely welcomed.

Effective Concentrations

To see results with just about any supplement, the concentrations per serving need to be realistic. If our team noticed that prices and doses were inversely related (i.e., low concentration and high prices), we refrained from including them in our list. Why pay so much money if the same amount of nutrients can be gathered through whole foods at a much lower cost right? It is important to note that scientifically backed ingredients and effective concentrations go together because findings are often reported based on specific doses administered. For instance, if researchers investigated the effects of 500mg Vitamin C on immunity and reported improvement, will a dose of 200mg deliver similar results at a similar rate? Probably not.

Health Claims

Dietary supplements are neither reviewed nor approved by the FDA for their safety and effectiveness. Above all, these supplements cannot make claims about diagnosis, cure, mitigation, or treatment of a disease. If such claims are made, individuals should turn the other way, as this might be a mere attempt at luring victims into buying a product filled with ineffective fillers. For more information on what the FDA does and does not approve, along with the types of claims that individuals should be watchful of, click here.

Manufacturing Processes

Manufacturing processes need to be within the U.S., in an FDA-approved, GMP-certified facility. Outsourcing ingredients can be problematic because there’s very little control over the growing and harvesting processes and the fact that each country has its own rules and regulations can lead to unwanted hurdles. If a company failed to provide crucial information pertaining to the actual contents of the immunity boosters, their product did not make the cut. Likewise, mentioning outsourcing, but providing very little substance/transparency led to seeking alternative solutions. From our standpoint, it is unrealistic to take such risks!

Money-Back Guarantees

Not all dietary supplements are likely to bring results. In fact, given how unique everyone is regarding their health, the rate at which results are attained or improvements are witnessed can fluctuate significantly. With supplements, long-term uses are desired to experience its full effects. For this reason, companies tend to promote bulk purchases at reduced rates. If there is no money-back guarantee for the unused bottles, they become useless. Who can forget the amount of money that would essentially go to waste?


Once again, price as a factor is important, but to a lesser extent than the above factors. Price alone doesn’t suggest anything about a product’s usefulness or the company’s background. However, it does give us hints when paired with other factors. For instance, if companies failed to be transparent about the ingredients, but expect consumers to pay $69 per bottle, it doesn’t make sense to invest. As previously mentioned, if the doses delivered are the bare minimum and the listed prices are simply unjustifiable, why invest!

In general, the above-ranking criteria can be adjusted based on one’s respective needs. The reason why we stuck by these six is that they are the most fundamental and sought-for factors that help to decide between different supplements. Evidently, for people with dietary restrictions and/or concerns surrounding allergens, the ranking criteria might be more detailed. All-in-all, we encourage everyone to use our ranking guideline as to the foundation and to polish it.

The Scientific Community’s Narrative on Immunity Boosters

The immune system is a delicate and life-changing component in our bodies, and it seems unreasonable to fuel it with just about any ingredient. To get things rolling and to stimulate everyone’s curiosity levels, we decided to research the top five ingredients common among most of our picks. Here’s what the scientific community has to share:

Vitamin C

Also known as L-ascorbic acid, vitamin C is a must seeing that it plays a vital role in collagen production, protein metabolism, and produces nutrients that upkeep our neurotransmitters. Most of all, it acts as an antioxidant that regenerates other antioxidants in the body, including vitamin E. As per one source, research on vitamin C ingestion has shown that it can limit the damaging effects of free radicals and might prevent or delay certain cancer types and diseases linked to oxidative stress (i.e., age-related macular degeneration, cataracts, and the common cold). Despite its potency, individuals who are following prescriptions will need to discuss its supplementation with a health practitioner, as vitamin C is best known to interact with other medications [1].

Vitamin D

Vitamin D has long been used to treat infections. Regarding its impact on the immune system, its effects were primarily witnessed among the innate and adaptive immune systems, explain one source. What caught us by surprise is the existence of epidemiologic evidence suggesting that vitamin D deficiency might give rise to a series of autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), diabetes mellitus (DM), inflammatory bowel disease, and systemic lupus erythematosus (SLE). Evidently, vitamin D ingestion can go beyond improving calcium intake and bone health. Since immune cells do in fact respond to vitamin D, it may tend to symptoms linked to an array of autoimmune diseases, which might explain why many immune boosters carry it [2].

Mushroom Complex (Shiitake, Reishi, and Maitake)

As per a 2019 review, shiitake, reishi, and maitake mushrooms carry a rich source of polysaccharides high in beta-glucans that promote an immunomodulatory response [3]. One study that evaluated the effect of mushroom beta-glucans found that it can increase natural killer (NK) cells in mice, preventing the overgrowth of the primary tumors [4]. Other potential benefits of ingesting mushrooms include reduced risk of cardiovascular disease and plaque formation in the arteries, DNA protection from oxidative damage, and high innate immune response [5].


Quercetin is a flavonoid known for its antioxidant activity, especially when it comes to scavenging free radicals and terminating them accordingly. Aside from its antioxidant property, quercetin has also been liked for its anti-inflammatory properties, which are essential in activating immune cells’ response. According to the claims made, this flavonoid works by neutralizing reactive oxygen species known to stimulate a hike in stress and mitochondrial dysfunction. At the time of writing, quercetin has also been found to reduce the impact of cytokine proteins, the spread of infections, and of course, can modulate the immune system. All things considered, more research will be needed to make firm conclusions, but the available results suggest a lot of promise [6].


Though used for as long as history can recount, turmeric is an Indian spice that recently made waves because of its anti-inflammatory properties. This stems from the embedded curcumin compound. So far, novel animal and human studies found that curcumin can directly affect immune cells including T lymphocyte subsets, macrophages, dendritic cells, and natural killers to say the least [7]. As for its usefulness, one source insists that “curcumin is one of the most promising phytochemicals that target various cancers and inflammation-mediated diseases.” Interestingly, clinical trials have been conducted on the uses of curcumin in the context of breast, pancreatic, and colorectal cancers, and multiple myeloma [8].

Immune Boosting Supplements Frequently Asked Questions (FAQS)

What is the immune system and why is it so important?

The immune system is a network of cells and proteins that work together to fight off infections, bacteria, and free radical damage. What might surprise many is that this system keeps a record of all its successful defeats so that foreign invaders are recognizable and destroyed almost instantly. Without an immune system, the body will be continuously attacked, limiting one’s chances for survival.

What are T cells and how do they differ from antibodies?

The immune system network consists of T cells, which have been tasked with attacking foreign particles. What makes these cells a vital component is that they work tirelessly to bring an end to invaders that they only stop circulating once their mission has been accomplished. On the other hand, we have immunoglobulin or antibodies, which are Y-proteins that recognize and latch onto antigens. The difference between the two is that the former can go as far as bringing an end to invaders, while antibodies can only latch onto and destroy outer cells.

What is the difference between innate and adaptive immunities?

Innate immune responses are deemed the first line of defense against foreign invaders, while adaptive immune responses are activated when innate immune responses do not suffice to control infection and/or bacterial presence. Simply put, when the first set of guards attack and are on the verge of failing, backup guards are sent out for support.

Can dietary changes support a healthy immune system?

Yes, in fact, individuals are asked to eat a diet high in fruits and vegetables, with emphasis placed on antioxidant and anti-inflammatory properties. Aside from dietary changes, lifestyle choices need reflection upon. This could include regular exercise and limiting alcohol consumption.

Does weight loss have a positive effect on the immune system?

Yes, weight loss can have a positive effect on the immune system. Some studies have confirmed that by losing weight, the pro-inflammatory nature of immune cells will have heightened, supporting heart health, easing arthritis symptoms, repairing damaged tissues, and creating a high defense system.

What can lower the immune system?

Nicotine, tobacco, alcohol, lack of sleep, stress, low vitamin D levels, and a high-fat diet among others can drastically weaken the body’s immune system.

In what ways are the gut and immune systems connected?

The gut and immune systems work to support each other for optimal immunity. For instance, the gut serves as the protector and ensures that T-cells understand how to distinguish the difference between good and bad players within the tissues. Another crucial piece of information is that the immune system accounts for 70% of the gut, practically making the two interconnected.

Do age, sex, and medicine influence immunity?

With age, one’s immunity is likely to weaken, failing to respond to calls at average rates. When it comes to sex, women have the upper hand because of their stronger bodily fluids and immune cell responses compared to men. Finally, we have medicine intake, and at higher doses, the immune system will be at risk of developing unwanted infections.

Is it true that stress can have a damaging effect on the immune system?

Yes, unfortunately, high stress levels give rise to a decrease in the body’s white blood cell count, which is necessary for fighting off infections. As white blood cells decrease in number, the risk of experiencing viruses is believed to skyrocket.

What do autoimmune disorders suggest about the strength of the immune system?

People who have been diagnosed with an autoimmune disease have an immune system that can’t tell the difference between parts of the body. To tell the truth, the body mistakes healthy cells for foreign invaders and ends up releasing autoantibodies to destroy its important components.

What are the side effects of taking immunity boosters?

Oftentimes, immunity boosters are known for their short-lived side effects. Specifically, they may range from a cough and nausea to a headache, constipation, and abdominal pain to say the least. It really boils down to the ingredient’s list, one’s own health, and how the two interact.

Top Immune Boosting Supplements Concluding Thoughts

The wellness of our immune systems should not be taken so lightly, as it can either make or break our health. Given how interconnected the immune system is with the rest of the body, one hindrance alone suffices to result in unwanted health implications. While dietary supplements are not meant to cure diseases, they can provide added support towards long-term wellness. With the 13 supplements discussed in this guide, individuals can feel a sense of relief as most of the companies are transparent and stuck by scientifically backed ingredients.

Taking everything into account, the next step should be to sit down with a health practitioner to see how any one of these supplements can be incorporated into one’s daily life. Until next time, we hope that this guide sparked interest in immune-boosting support systems and that the knowledge attained contributes to everyone’s wellness!

More Like This: Immune 11X Reviews (UpWellness) Boost Immunity Naturally?

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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