Oscar-winning, psychological thriller Silence of the Lambs forever changed the way we hear Tom Petty's "American Girl", thanks to the scene early in the movie where future kidnapping/torture victim Catherine Martin is pounding on her car's dashboard as she barrels down a rain-soaked highway, inadvertently en route to her attacker, Buffalo Bill.
However, the creepiest intersection of music and horror occurs when we peek inside the bedroom of Buffalo Bill and witness him in a moment of transgendered narcisism, applying lipstick, tucking his man parts back between his legs, and dancing with his own Hedwig-meets-Leatherface image while Q Lazzarus' "Goodbye Horses" echoes eerily in the background.
That original disturbing clip is pretty much impossible to find on Youtube. However, there are about 9,000 parodies (scary in an entirely different way), as well as Jay and Silent Bob's subsequent interpretation of the scene (from director Kevin Clark's Clerks 2), and the Airborne Toxic Event's live cover of the song. Both are after the jump.